Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Topical application of integrin antagonists inhibits proliferative retinopathy
Autore:
Riecke, B; Chavakis, E; Bretzel, RG; Linn, T; Preissner, KT; Brownlee, M; Hammes, HP;
Indirizzi:
Univ Heidelberg, Hosp Mannheim, Dept Med 5, D-68167 Mannheim, Germany UnivHeidelberg Mannheim Germany D-68167 ed 5, D-68167 Mannheim, Germany Univ Giessen, Dept Med 3, D-35390 Giessen, Germany Univ Giessen Giessen Germany D-35390 ept Med 3, D-35390 Giessen, Germany Univ Giessen, Inst Biochem, D-35390 Giessen, Germany Univ Giessen Giessen Germany D-35390 t Biochem, D-35390 Giessen, Germany Albert Einstein Coll Med, Diabet Res Ctr, Bronx, NY 10467 USA Albert Einstein Coll Med Bronx NY USA 10467 Res Ctr, Bronx, NY 10467 USA
Titolo Testata:
HORMONE AND METABOLIC RESEARCH
fascicolo: 5, volume: 33, anno: 2001,
pagine: 307 - 311
SICI:
0018-5043(200105)33:5<307:TAOIAI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; ALPHA-V INTEGRINS; RETINAL NEOVASCULARIZATION; MURINE MODEL; DIABETIC-RETINOPATHY; CELL-ADHESION; RGD PEPTIDES; RECEPTOR; ALPHA(V)BETA(3); ANGIOGENESIS;
Keywords:
diabetic retinopathy; angiogenesis; alpha(v)-type integrins; RGD peptides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Hammes, HP Univ Heidelberg, Hosp Mannheim, Dept Med 5, D-68167 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68167 67 Mannheim, Germany
Citazione:
B. Riecke et al., "Topical application of integrin antagonists inhibits proliferative retinopathy", HORMONE MET, 33(5), 2001, pp. 307-311

Abstract

The expression of alpha (v)-integrins is highly selective for angiogenic endothelial cells; ligation inhibition by cyclic RGD peptides prevents pathological neovascularization in tumor or retinopathy models to a large extent. We have previously demonstrated that proliferative retinopathy in a mousemodel of retinopathy of prematurity (ROP model) can be reduced by more than 70%. To minimize systemic side effects and unwanted interference with responsive angiogenesis, we investigated topical application of cyclic RGD-peptides. In preliminary experiments, we could exclude any inhibiting effects of the carrier solution containing EDTA, Na,S, mannitol, hydroxyethyl starch, and benzalconium chloride on the inhibitory effect of cyclic RGD peptides. Retinal presence of small molecular-mass integrin antagonists after topical application was confirmed using fluorescein-labeled cyclic RGD peptide. Topical application of the peptide to the eye inhibited proliferative retinopathy in a dose-dependent fashion with a maximum of almost 50 %. These results suggest that small molecular-mass peptide antagonists of alpha (v)-type integrins are efficient in inhibiting proliferative retinopathy by topical application.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:55:42