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Titolo:
Interferon alpha inhibits intrahepatic recurrence in hepatocellular carcinoma with chronic hepatitis C: a pilot study
Autore:
Suou, T; Mitsuda, A; Koda, M; Matsuda, H; Maruyama, S; Tanaka, H; Kishimoto, Y; Michimori, K; Hirooka, Y; Kawasaki, H;
Indirizzi:
Tottori Univ, Fac Med, Dept Internal Med 2, Yonago, Tottori 6838504, JapanTottori Univ Yonago Tottori Japan 6838504 Yonago, Tottori 6838504, Japan Tottori Red Cross, Dept Internal Med, Tottori, Japan Tottori Red Cross Tottori Japan ross, Dept Internal Med, Tottori, Japan Gotsu Gen Hosp, Dept Internal Med, Gotsu, Japan Gotsu Gen Hosp Gotsu Japan su Gen Hosp, Dept Internal Med, Gotsu, Japan Toyooka Hosp, Dept Internal Med, Toyooka, Japan Toyooka Hosp Toyooka Japan ooka Hosp, Dept Internal Med, Toyooka, Japan San In Rosai Hosp, Dept Internal Med, Yonago, Tottori, Japan San In Rosai Hosp Yonago Tottori Japan ernal Med, Yonago, Tottori, Japan Matsue Municipal Hosp, Dept Internal Med, Matsue, Shimane, Japan Matsue Municipal Hosp Matsue Shimane Japan l Med, Matsue, Shimane, Japan Tottori Univ, Fac Med, Dept Surg 1, Yonago, Tottori 6838504, Japan TottoriUniv Yonago Tottori Japan 6838504 Yonago, Tottori 6838504, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 3, volume: 20, anno: 2001,
pagine: 301 - 311
SICI:
1386-6346(200107)20:3<301:IAIIRI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; ETHANOL INJECTION THERAPY; RISK-FACTORS; NONCIRRHOTIC PATIENTS; ALFA THERAPY; VIRUS-RNA; NON-A; NON-B; CARCINOGENESIS; RESECTION;
Keywords:
interferon alpha; intrahepatic recurrence; hepatocellular carcinoma; chronic hepatitis C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Suou, T Tottori Univ, Fac Med, Dept Internal Med 2, Nishi Machi 36-1, Yonago, Tottori 6838504, Japan Tottori Univ Nishi Machi 36-1 Yonago Tottori Japan 6838504 , Japan
Citazione:
T. Suou et al., "Interferon alpha inhibits intrahepatic recurrence in hepatocellular carcinoma with chronic hepatitis C: a pilot study", HEPATOL RES, 20(3), 2001, pp. 301-311

Abstract

The aim of the present study is to evaluate whether interferon alpha (IFN alpha) therapy can inhibit intrahepatic recurrence after the curative treatment of small HCC with underlying chronic hepatitis C. Forty patients were enrolled in this study. They had solitary, small HCC less than or equal to 3 cm in diameter, underlying chronic hepatitis C, and were less than or equal to 70 years old. Of the patients, 18 were treated with IFN alpha for 6 months after the treatment of HCC, and 22 patients who did not receive IFN alpha therapy were used as controls. Six (33%) patients in the IFN group showed sustained response. The incidence of local recurrence was not differentin the IFN and non-IFN groups (6 vs. 9%). The cumulative incidences of distant recurrence in the non-IFN and IFN groups were 9 and 6% at 1 year, 27 and 11% at 2 years, 63 and 18% at 3 years, 76 and 28% at 4 years, and 82 and28% at 5 years; they were significantly different (P < 0.01). Six (27%) patients in the non-IFN group died from the progression of HCC. but all IFN-treated patients were alive (P < 0.05). The pilot study demonstrates that IFN alpha therapy after the curative treatment of small HCC can inhibit intrahepatic recurrence in the remnant liver and improve the prognosis of hepatitis: C virus-related HCC. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 22/01/20 alle ore 19:15:26