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Titolo:
Relation between cytokines and Helicobacter pylori in gastric cancer
Autore:
Yamaoka, Y; Kodama, T; Kita, M; Imanishi, J; Kashima, K; Graham, DY;
Indirizzi:
Vet Affairs Med Ctr, Dept Med, Houston, TX 77030 USA Vet Affairs Med Ctr Houston TX USA 77030 Dept Med, Houston, TX 77030 USA Baylor Coll Med, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ylor Coll Med, Houston, TX 77030 USA Kyoto Prefectural Univ Med, Dept Internal Med 3, Kyoto 602, Japan Kyoto Prefectural Univ Med Kyoto Japan 602 ernal Med 3, Kyoto 602, Japan Kyoto Prefectural Univ Med, Dept Microbiol, Kyoto 602, Japan Kyoto Prefectural Univ Med Kyoto Japan 602 t Microbiol, Kyoto 602, Japan
Titolo Testata:
HELICOBACTER
fascicolo: 2, volume: 6, anno: 2001,
pagine: 116 - 124
SICI:
1083-4389(2001)6:2<116:RBCAHP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-6 LEVELS CORRELATE; MONGOLIAN GERBILS; DISEASE STATUS; SERUM LEVELS; CAGA GENE; CARCINOMA; INFECTION; EXPRESSION; MUCOSA; IL-6;
Keywords:
Helicobacter pylori; gastric cancer; cytokines; interleukin-6; interleukin-8;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Yamaoka, Y Vet Affairs Med Ctr, Dept Med, 111D,2002 Holcombe Blvd, Houston, TX 77030 USA Vet Affairs Med Ctr 111D,2002 Holcombe Blvd Houston TX USA 77030
Citazione:
Y. Yamaoka et al., "Relation between cytokines and Helicobacter pylori in gastric cancer", HELICOBACT, 6(2), 2001, pp. 116-124

Abstract

Background. Helicobacter pylori is etiologically involved in the development of gastric cancer and infected gastric mucosa has been shown to possess elevated levels of cytokines [for example interleukin (IL)-1 beta, IL-6 andIL-8]. Because specific cytokines have also been shown to enhance the development of certain cancers, we examined the relationship between the levelsof cytokines, the type and stage of gastric cancers, and the H. pylori infection. Materials and Methods. Cytokines were measured from gastric cancer tissues, adjacent normal appearing mucosa, and the serum in 66 patients with earlyor advanced gastric cancer and from controls using semiquantitative RT-PCRand ELISA. Results. IL-6 and IL-8 levels were more than 10-fold increased in cancer tissues as compared with normal gastric tissues. IL-8 levels in cancer tissues were more than 2-fold higher in advanced gastric cancer as compared withearly gastric cancer irrespective of H. pylori status. IL-6 levels were significantly higher in early gastric cancer with active H. pylori infection as compared with early cancer without H, pylori infection (8.7 + 1.4 vs. 1.2 + 0.3 pg/mg protein, p <.001) and decreased significantly after the cure of H. pylori (11.1 + 2.9-8.2 + 2.3 pg/mg protein, p<.05). Conclusions. IL-8 levels in gastric cancer tissue are largely independent of H. pylori infection. In contrast, tissue IL-6 levels were high in H. pylori infected early gastric cancer and fell significantly after the cure of H. pylori suggesting a relationship between H. pylori infection and early gastric cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 13:52:46