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Titolo:
No substantial difference in genotype frequencies of interleukin and myeloperoxidase polymorphisms between malignant lymphoma patients and non-cancercontrols
Autore:
Matsuo, K; Hamajima, N; Suzuki, R; Nakamura, S; Seto, M; Morishima, Y; Tajima, K;
Indirizzi:
Aichi Canc Ctr, Inst Res, Div Epidemiol & Prevent, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 u, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr, Div Mol Med, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 d, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr, Dept Hematol & Chemotherapy, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 y, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr, Div Pathol & Genet, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 t, Nagoya, Aichi 4648681, Japan Nagoya Univ, Grad Sch Med, Dept Epidemiol, Nagoya, Aichi, Japan Nagoya Univ Nagoya Aichi Japan Med, Dept Epidemiol, Nagoya, Aichi, Japan
Titolo Testata:
HAEMATOLOGICA
fascicolo: 6, volume: 86, anno: 2001,
pagine: 602 - 608
SICI:
0390-6078(200106)86:6<602:NSDIGF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST GENE; FAS-MEDIATED APOPTOSIS; DISEASE SEVERITY; AUTOCRINE GROWTH; MULTIPLE-MYELOMA; STRAND BREAKS; PLASMA-LEVELS; RISK; MONOCYTES; CYTOKINES;
Keywords:
malignant lymphoma; genetic predisposition of disease; IL-1; myeloperoxidase; gene polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuo, K Aichi Canc Ctr, Inst Res, Div Epidemiol & Prevent, Chikusa Ku, 1-1 Kanokoden, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr 1-1 Kanokoden Nagoya Aichi Japan 4648681 1, Japan
Citazione:
K. Matsuo et al., "No substantial difference in genotype frequencies of interleukin and myeloperoxidase polymorphisms between malignant lymphoma patients and non-cancercontrols", HAEMATOLOG, 86(6), 2001, pp. 602-608

Abstract

Background and Objectives. The functional polymorphisms regulating immunologic responses may influence the proliferation or suppression of malignant lymphoma. We examined the association between malignant lymphoma risk and the polymorphisms of the IL-1 gene family [IL-1B -31 C/T, IL-1A -889 C/T, and IL-1RN 86-bp variable number of terminal repeat (VNTR)] and myeloperoxidase (MPO -463 G/A). Design and Methods. The hospital-based case-control study was conducted inJapan. Genotypes were examined in a total of 372 lymphoma cases and 241 non-cancer control subjects. The relative risks were estimated by unconditional logistic regression analysis. Results. The overall allele distribution of these polymorphisms did not differ substantially between patients and controls; the odds ratios were 0.73(95% confidence interval, 0.48-1.11) for the T allele carders of IL-1B relative to the non-carriers, 1.01 (0.56-1.82) for the repeat allele (allele 2) carders of IL-1RN, 0.96 (0.62-1.48) for the T allele carriers of IL-1A, and 1.04 (0.70-1.57) for the A allele carriers of MPO. Subgroup analyses according to histology [diffuse large B-cell lymphoma (DLBL), follicular lymphoma, low-grade lymphoma of mucosa associated lymphoid tissue, and others] failed to illustrate differences except for DLBL which showed a possible association with IL-1A and IL-1B polymorphisms. Interpretation and Conclusions. Our data show a limited association between these polymorphisms and malignant lymphoma risk in total. The possible association of the IL-1A and IL-1B polymorphisms with DLB-needs further clarification. (C) 2001, Ferrata Stolti Foundation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 05:56:24