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Titolo:
Coordination between transcription and pre-mRNA processing
Autore:
Cramer, P; Srebrow, A; Kadener, S; Werbajh, S; de la Mata, M; Melen, G; Nogues, G; Kornblihtt, AR;
Indirizzi:
Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Ciencias Biol, Lab Fisiol & Biol Mol, RA-1428 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1428 Aires, DF, Argentina Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA Harvard Univ Cambridge MA USA 02138 ellular Biol, Cambridge, MA 02138 USA
Titolo Testata:
FEBS LETTERS
fascicolo: 2-3, volume: 498, anno: 2001,
pagine: 179 - 182
SICI:
0014-5793(20010608)498:2-3<179:CBTAPP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA-POLYMERASE-II; C-TERMINAL DOMAIN; MESSENGER-RNA; EXON DEFINITION; CAPPING ENZYME; PHOSPHORYLATION; GENE; POLYADENYLATION; ASSOCIATION; ELONGATION;
Keywords:
RNA polymerase II; mRNA processing; carboxy-terminal domain; coupling;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Kornblihtt, AR Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Ciencias Biol, Lab Fisiol & Biol Mol, Ciudad Univ,Pabellon 2,C1428EHA, RA-1428 Buenos Aires, DF, Argentina Univ Buenos Aires Ciudad Univ,Pabellon 2,C1428EHA Buenos Aires DF Argentina RA-1428
Citazione:
P. Cramer et al., "Coordination between transcription and pre-mRNA processing", FEBS LETTER, 498(2-3), 2001, pp. 179-182

Abstract

A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing, (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

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Documento generato il 30/11/20 alle ore 06:23:46