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Titolo:
Primary sequence requirements for S-acylation of beta(2)-adrenergic receptor peptides
Autore:
Belanger, C; Ansanay, H; Qanbar, R; Bouvier, M;
Indirizzi:
Univ Montreal, Dept Biochim, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 im, Montreal, PQ H3C 3J7, Canada Univ Montreal, Grp Rech Syst Nerveux Autonome, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 me, Montreal, PQ H3C 3J7, Canada
Titolo Testata:
FEBS LETTERS
fascicolo: 1-2, volume: 499, anno: 2001,
pagine: 59 - 64
SICI:
0014-5793(20010615)499:1-2<59:PSRFSO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN PROTEOLIPID PROTEIN; POLYBASIC DOMAIN; PLASMA-MEMBRANE; BETA-2-ADRENERGIC RECEPTOR; STRUCTURAL REQUIREMENTS; VIRAL GLYCOPROTEINS; COUPLED RECEPTORS; COENZYME-A; CAAX MOTIF; ACYL-COAS;
Keywords:
palmitoylation; acylation; post-translational modification; palmitoyl-CoA; G protein-coupled receptor; beta(2)-adrenergic receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Bouvier, M Univ Montreal, Dept Biochim, CP 6128,Succursale Ctr Ville, Montreal, PQ H3C 3J7, Canada Univ Montreal CP 6128,Succursale Ctr Ville Montreal PQ Canada H3C 3J7
Citazione:
C. Belanger et al., "Primary sequence requirements for S-acylation of beta(2)-adrenergic receptor peptides", FEBS LETTER, 499(1-2), 2001, pp. 59-64

Abstract

Palmitoylation is a post-translational modification that occurs on selected cysteines of many proteins. Since a high proportion of basic and hydrophobic residues is often found near the palmitoylated cysteine, the role of these residues in the selection of specific palmitoylation sites was assessed. Short peptides derived from the beta (2)-adrenergic receptor sequence, modified to present different proportions of basic, acidic and hydrophobic residues, were tested in an in vitro S-acylation assay. Basic residues provedto be essential, whereas hydrophobic residues greatly enhanced S-acylationand acidic residues inhibited it. Taken together, these results show that short peptides contain tile required molecular determinants leading to selective S-acylation. Whether or not these sequence characteristics also contribute to the selectivity of palmitoylation in vivo will need to be further investigated. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 23:51:00