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Titolo:
Transplantation of normal islets into the portal vein of Otsuka Long EvansTokushima Fatty rats prevents diabetic progression
Autore:
Katsuragi, I; Okeda, T; Yoshimatsu, H; Utsunomiya, N; Ina, K; Sakata, T;
Indirizzi:
Oita Med Univ, Sch Med, Dept Internal Med 1, Oita 8795593, Japan Oita Med Univ Oita Japan 8795593 ept Internal Med 1, Oita 8795593, Japan Oita Med Univ, Sch Med, Dept Anat, Oita 8795593, Japan Oita Med Univ Oita Japan 8795593 Sch Med, Dept Anat, Oita 8795593, Japan Oita Med Univ, Sch Nursing, Oita 8795593, Japan Oita Med Univ Oita Japan8795593 Univ, Sch Nursing, Oita 8795593, Japan
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 7, volume: 226, anno: 2001,
pagine: 681 - 685
SICI:
1535-3702(200107)226:7<681:TONIIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC-ISLETS; INSULIN SENSITIVITY; OLETF STRAIN; MELLITUS; PATHOGENESIS; NIDDM; MICE;
Keywords:
diabetes; transplantation; pancreatic islet; portal vein; insulin resistance; OLETF rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Sakata, T Oita Med Univ, Sch Med, Dept Internal Med 1, 1-1 Idaigaoka, Oita8795593, Japan Oita Med Univ 1-1 Idaigaoka Oita Japan 8795593 a 8795593, Japan
Citazione:
I. Katsuragi et al., "Transplantation of normal islets into the portal vein of Otsuka Long EvansTokushima Fatty rats prevents diabetic progression", EXP BIOL ME, 226(7), 2001, pp. 681-685

Abstract

To investigate the long-term effects of normal pancreatic islet transplantation on progression of obese type 2 diabetes mellitus (DM), 1500 normal islets (per rat) from Wistar King A rats at 8 weeks of age were transplanted into the liver through the portal vein of Otsuka Long Evans Tokushima Fatty(OLETF) rats, an animal model of obese type 2 DM, at 12 weeks of age. Bodyweight in the transplanted OLETF (IT) rats 8 and 28 weeks after Islet transplantation did not differ from that in the corresponding sham-operated (SO) rats, but was greater than that in lean littermates (LETO rats; P < 0.05 for each group). In the early phase, 8 weeks after transplantation, rats inboth IT and SO groups were normoglycemic, but hyperinsulinemic (P < 0.05 for each compared with LETO rats), probably resulting from increased body weight. In the late phase, 28 weeks after transplantation, hyperglycemia in the IT group was greatly attenuated compared with the SO group (P < 0.05), but hyperinsulinemia remained in both the IT and the SO groups compared withthat in the LETO group (P E 0.05 for each). Immunohistochemical studies demonstrated that hypertrophic and fibrotic changes in pancreatic Islets, together with mesangial proliferation of the glomerular matrix, an indicator for diabetic nephropathy, were attenuated predominantly in the IT group at the late phase after transplantation compared with those in the corresponding phase of the SO group. Islet transplantation into the liver of OLETF ratsthus prevented further progression of obese type 2 DM. A possible mechanism Is that islet transplantation may prevent development of hyperglycemia byimproving abnormal hepatic glucose metabolism and consequently Insulin resistance, which may lead to blockade of a vicious cycle between advancing damage to pancreatic islet cells and increased demand for insulin secretion, thus sparing original pancreatic cells from exhaustion induced by increaseddemand for insulin secretion.

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Documento generato il 25/01/20 alle ore 16:51:13