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Titolo:
Ontogenic regulation of components of ileal bile acid absorption
Autore:
Hwang, ST; Henning, SJ;
Indirizzi:
Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 , Dept Pediat, Houston, TX 77030 USA Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Cellular Biol, Houston, TX 77030 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 7, volume: 226, anno: 2001,
pagine: 674 - 680
SICI:
1535-3702(200107)226:7<674:OROCOI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOSTEROID-BINDING GLOBULIN; BORDER MEMBRANE-VESICLES; RAT SMALL-INTESTINE; MESSENGER-RNA; POSTNATAL-DEVELOPMENT; CIRCULATING CORTICOSTERONE; SALT TRANSPORT; SUCKLING RAT; FOOD-INTAKE; THYROXINE;
Keywords:
ASBT; IBABP; intestinal development; glucocorticoid; thyroxine; weaning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Hwang, ST Baylor Coll Med, Dept Pediat, 1 Baylor Plaza, Houston, TX 77030 USA Baylor Coll Med 1 Baylor Plaza Houston TX USA 77030 TX 77030 USA
Citazione:
S.T. Hwang e S.J. Henning, "Ontogenic regulation of components of ileal bile acid absorption", EXP BIOL ME, 226(7), 2001, pp. 674-680

Abstract

The apical sodium-dependent bile acid cotransporter (ASBT) and the ileal bile acid binding protein (IBABP) are two components of ileal bile acid absorption. During the third postnatal week of the rat, there is a dramatic increase in ASBT and IBABP expression. The goals of this study were to examinethe role of hormones on the ontogenic expression of ASBT mRNA and the roleof weaning for both ASBT and IBABP mRNA. Administration of various doses of dexamethasone during the second postnatal week induced ASBT mRNA levels, and this effect was significantly increased with concomitant thyroxine treatment. Early weaning and weaning prevention were utilized to investigate the influence of dietary factors. ASBT and IBABP mRNA levels were significantly elevated by early weaning and were decreased by weaning prevention compared with littermate controls. Thus, glucocorticoids and thyroxine appear toplay a role in the ontogenic expression of ASBT mRNA and weaning appears to participate in both ASBT and IBABP expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:47:17