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Titolo:
Copper control as an antiangiogenic anticancer therapy: Lessons from treating Wilson's disease
Autore:
Brewer, GJ;
Indirizzi:
Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Human Genet, Ann Arbor, MI 48109 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 7, volume: 226, anno: 2001,
pagine: 665 - 673
SICI:
1535-3702(200107)226:7<665:CCAAAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; NEUROLOGICALLY AFFECTED PATIENTS; VASCULAR-PERMEABILITY FACTOR; SACCHAROMYCES-CEREVISIAE; TUMOR ANGIOGENESIS; PODOSPORA-ANSERINA; INITIAL THERAPY; AMMONIUM TETRATHIOMOLYBDATE; TRANSCRIPTION FACTOR; FOLLOW-UP;
Keywords:
copper; angiogenesis; cancer; tetrathiomolybdate; zinc;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Brewer, GJ Univ Michigan, Dept Human Genet, 4909 Buhl Bldg, Ann Arbor, MI 48109 USA Univ Michigan 4909 Buhl Bldg Ann Arbor MI USA 48109 I 48109 USA
Citazione:
G.J. Brewer, "Copper control as an antiangiogenic anticancer therapy: Lessons from treating Wilson's disease", EXP BIOL ME, 226(7), 2001, pp. 665-673

Abstract

The search for new anticopper drugs for Wilson's disease is culminating intwo excellent new drugs: zinc for maintenance therapy and tetrathiomolybdate (TM) for initial therapy. Both are effective and nontoxic. TM is a very potent, fast-acting new anticopper drug and its properties may be useful well beyond Wilson's disease. Angiogenesis (new blood vessel growth) is required for tumor growth, and a sufficient level of copper appears to be required for angiogenesis, We hypothesize that there is a "window" to which the copper level can be reduced that inhibits angiogenesis in tumors, but does not interfere with vital cellular functions of copper. Using TM therapy, this approach has worked to slow or stabilize tumor growth in several animal tumor models, and preliminary results are also very encouraging in human patients with a variety of advanced and metastatic malignancies. A hypothesis is advanced that copper availability has played a fundamental role in growth regulation throughout evolution and that is the reason that so many angiogenic promoters appear to be dependent upon copper levels.

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Documento generato il 18/01/21 alle ore 15:23:12