Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Corneal epithelial wound healing
Autore:
Lu, L; Reinach, PS; Kao, WWY;
Indirizzi:
Wright State Univ, Sch Med, Dept Physiol & Biophys, Dayton, OH 45435 USA Wright State Univ Dayton OH USA 45435 iol & Biophys, Dayton, OH 45435 USA SUNY Coll Optometry, Dept Biol Sci, New York, NY 10010 USA SUNY Coll Optometry New York NY USA 10010 iol Sci, New York, NY 10010 USA Univ Cincinnati, Coll Med, Dept Ophthalmol, Cincinnati, OH USA Univ Cincinnati Cincinnati OH USA d, Dept Ophthalmol, Cincinnati, OH USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 7, volume: 226, anno: 2001,
pagine: 653 - 664
SICI:
1535-3702(200107)226:7<653:CEWH>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; PROTEIN-KINASE-C; CHONDROITIN SULFATE PROTEOGLYCAN; PRECURSOR-LIKE PROTEIN-2; STRATIFIED SQUAMOUS EPITHELIUM; SIGNAL-TRANSDUCTION PATHWAYS; SUBSTANCE-P; PHOTOREFRACTIVE KERATECTOMY; GLUCOSE-TRANSPORTER; K+ CHANNELS;
Keywords:
apoptosis; cell proliferation; cytokines; growth factor receptors; K+ channel;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
169
Recensione:
Indirizzi per estratti:
Indirizzo: Lu, L Wright State Univ, Sch Med, Dept Physiol & Biophys, Dayton, OH 45435USA Wright State Univ Dayton OH USA 45435 Biophys, Dayton, OH 45435 USA
Citazione:
L. Lu et al., "Corneal epithelial wound healing", EXP BIOL ME, 226(7), 2001, pp. 653-664

Abstract

One of the important functions of the cornea is to maintain normal vision by refracting light onto the lens and retina. This property is dependent inpart on the ability of the corneal epithelium to undergo continuous renewal. Epithelial renewal is essential because it enables this tissue to act asa barrier that protects the corneal interior from becoming infected by noxious environmental agents, Furthermore, the smooth optical properties of the corneal epithelial surface are sustained through this renewal process. The rate of renewal is dependent on a highly integrated balance between the processes of corneal epithelial proliferation, differentiation, and cell death. One experimental approach to characterize these three aspects of the renewal process has been to study the kinetics and dynamics of corneal re-epithelialization in a wound-healing model. This effort has employed in vivo and in vitro studies. From such studies it is evident that the appropriate integration and coordination of corneal epithelial proliferation, adhesion, migration, and cell demise is dependent on the actions of a myriad of cytokines. Our goal here is to provide an overview into how these mediators and environmental factors elicit control of cellular proliferation, adhesion, migration, and apoptosis, To this end we review the pertinent literature dealing with the receptor and the cell signaling events that are responsible for mediating cytokine control of corneal epithelial renewal, It is our hopethat a better appreciation can be obtained about the complexity of the control processes that are responsible for assuring continuous corneal epithelial renewal in health and disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:40:31