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Titolo:
Treatment of dyslipoproteinemia in the metabolic syndrome
Autore:
Steinmetz, A; Fenselau, S; Schrezenmeir, J;
Indirizzi:
Univ Bonn, Teaching Hosp, St Nikolaus Stiftshosp GmbH Andernach, D-56626 Andernach, Germany Univ Bonn Andernach Germany D-56626 ndernach, D-56626 Andernach, Germany Fed Res Ctr, Inst Physiol & Biochem, Kiel, Germany Fed Res Ctr Kiel Germany Res Ctr, Inst Physiol & Biochem, Kiel, Germany
Titolo Testata:
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
fascicolo: 4, volume: 109, anno: 2001,
pagine: S548 - S559
SICI:
0947-7349(2001)109:4<S548:TODITM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; LOW-DENSITY-LIPOPROTEIN; TRIGLYCERIDE-RICH LIPOPROTEINS; SCANDINAVIAN SIMVASTATIN SURVIVAL; ORAL LIPID LOAD; HIGH-FAT MEAL; ARTERY DISEASE; ENDOTHELIAL-CELLS; MYOCARDIAL-INFARCTION; CHYLOMICRON REMNANTS;
Keywords:
metabolic syndrome; dyslipidemia; diabetes; drug therapy; statins; fibrates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Steinmetz, A Univ Bonn, Teaching Hosp, St Nikolaus Stiftshosp GmbH Andernach, Hindenburgwall 1, D-56626 Andernach, Germany Univ Bonn Hindenburgwall 1Andernach Germany D-56626 Germany
Citazione:
A. Steinmetz et al., "Treatment of dyslipoproteinemia in the metabolic syndrome", EXP CL E D, 109(4), 2001, pp. S548-S559

Abstract

The metabolic syndrome consists of a cluster of metabolic disorders, many of which promote the development of atherosclerosis and increase the risk to develop cardiovascular disease. The metabolic syndrome is characterized by atherogenic dyslipidemia (elevated triglycerides. increased small dense low-density lipoproteins. and decreased high-density lipoproteins). hypertension, insulin resistance and obesity. To decrease the risk of cardiovascular disease events decreasing body weight by ingesting a healthy diet. increasing physical activity. cessation of smoking and managing dyslipidemia are recommended. pharmacological treatment of dyslipidemia is based on different drug classes. For LDL-cholesterol-lowering mainly statins and for triglyceride-lowering mainly fibrates are used. In primary and secondary prevention trials of heart disease they have shown to reduce the incidence of coronary artery disease or coronary events by 25-60 percent. Statins reduce mainly LDL-cholesterol levels by competitive inhibition of HMG-CoA reductase buthave also shown to reduce fasting and postprandial triglyceride levels. Fibrates effectively reduce fasting and postprandial lipemia, shift the distribution of LDL particles towards less dense particles and increase HDL-cholesterol. Thus fibrates particularly address components of the metabolic syndrome and features of diabetic dyslipidemia. However studies still are needed showing definite evidence on differential therapy in lipid lowering based on prospective controlled trials with endpoints of macro- and microangiopathy in diabetic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:50:59