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Titolo:
Postprandial triglycerides and blood coagulation
Autore:
Silveira, A;
Indirizzi:
Karolinska Inst, Karolinska Hosp, King Gustaf V Res Inst, Atherosclerosis Res Unit, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Unit, S-17176 Stockholm, Sweden
Titolo Testata:
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
fascicolo: 4, volume: 109, anno: 2001,
pagine: S527 - S532
SICI:
0947-7349(2001)109:4<S527:PTABC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; ISCHEMIC-HEART-DISEASE; FACTOR-VII ACTIVITY; PLASMINOGEN-ACTIVATOR INHIBITOR; TISSUE FACTOR; RICH LIPOPROTEINS; DIETARY-FAT; FACTOR-IX; MYOCARDIAL-INFARCTION; FACTOR-XII;
Keywords:
factor VII; blood coagulation; plasminogen activator inhibitor-1 (PAI-I); postprandial triglycerides; alimentary lipemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Silveira, A Karolinska Inst, Karolinska Hosp, King Gustaf V Res Inst, Atherosclerosis Res Unit, S-17176 Stockholm, Sweden Karolinska Inst StockholmSweden S-17176 6 Stockholm, Sweden
Citazione:
A. Silveira, "Postprandial triglycerides and blood coagulation", EXP CL E D, 109(4), 2001, pp. S527-S532

Abstract

Most of our lifetime we spend in the postprandial state. Postprandial triglyceridemia may represent a procoagulant state involving disturbances of both blood coagulation and fibrinolysis, in particular due to elevation of the plasma levels of activated factor VII (VIIa) and plasminogen activator inhibitor (PAI-1). Therefore. disturbances of the hemostatic system might, atleast partly, account for by the link between hypertriglyceridemia and coronary heart disease (CHD). - Factor VIIa is the first enzyme of the blood coagulation system and serves a priming function for triggering of the clotting cascade. The coagulant activity of factor VII (VIIc, total activity of factor VII in plasma) was identified as an independent predictor of myocardial infarction in initially healthy middle-aged men. and particularly of Fatal coronary events. and both serum cholesterol and triglyceride concentrations correlated positively with the VIIc level. Addition of fat to diet hasbeen consistently shown to cause a rapid conversion of the factor VII zymogen into its active form (VIIa) whereas the concentration of total protein is unaffected. Postprandial activation of factor VII is dependent on lipolytic activity and it is mainly supported by large triglyceride-rich lipoprotein of the VLDL class. Studies in vivo with specific coagulation factor-deficient patients indicate that factor IX is essential for the postprandial activation of factor VII. The basal generation of thrombin seems to be unaffected by increased plasma levels of VIIa. However, since VIla-tissue factorcomplex is responsible for the initiation of the coagulation cascade, increased generation of VIIa in the post prandial state would increase the potential for thrombin production in the event of plaque rupture. - Plasminogenactivator inhibitor-1 (PAI-1) is the major physiological inhibitor of the plasminogen activators in the circulation and thereby the: principal inhibitor of the fibrinolytic system. Postprandial triglyceridemia has been observed in many. not all. studies to increase PAI-1 plasma levels, which would further strengthen the chances of thrombotic occlusion of a vessel after rupture of an atherosclerotic plaque.

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Documento generato il 15/07/20 alle ore 06:00:06