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Titolo:
Changes in the control of gonadotrophin secretion by neurotransmitters during sexual development in rats
Autore:
Moguilevsky, JA; Wuttke, W;
Indirizzi:
Buenos Aires Med Sch, Dept Physiol, Buenos Aires, DF, Argentina Buenos Aires Med Sch Buenos Aires DF Argentina enos Aires, DF, Argentina Univ Gottingen, Dept Obstet & Gynecol, Div Clin & Expt Endocrinol, D-3400 Gottingen, Germany Univ Gottingen Gottingen Germany D-3400 rinol, D-3400 Gottingen, Germany
Titolo Testata:
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
fascicolo: 4, volume: 109, anno: 2001,
pagine: 188 - 195
SICI:
0947-7349(2001)109:4<188:CITCOG>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING HORMONE; N-METHYL-D; AMINO-ACID NEUROTRANSMISSION; PREPUBERTAL FEMALE RATS; LUTEINIZING-HORMONE; SEROTONINERGIC SYSTEM; OVARIECTOMIZED RATS; D-ASPARTATE; LH-RELEASE; GABAERGIC CONTROL;
Keywords:
puberty; GnRH; neurotransmitters; sexual maturation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Moguilevsky, JA Univ Buenos Aires, Fac Med, Dept Fisiol, Paraguay 2155,Piso 7, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Paraguay 2155,Piso 7 Buenos Aires DF Argentina RA-1121
Citazione:
J.A. Moguilevsky e W. Wuttke, "Changes in the control of gonadotrophin secretion by neurotransmitters during sexual development in rats", EXP CL E D, 109(4), 2001, pp. 188-195

Abstract

Gonadotrophin hormone releasing hormone (GnRH) is the primary messenger involved in sexual maturation and the onset of puberty. The activity of theseneurons are controlled by several neurotransmitters systems. The onset of puberty implies changes from a prepubertal type of gonadotrophin secretion,characterized by a low activity of GnRH neurons. to an adult pattern of secretion with phasic and synchronous activation of GnRH neurons resulting inan increase in the amplitude and frequency of GnRH pulses. Neurotransmitter systems are involved in these changes of GnRH secretion during the onset of puberty by quantitative and qualitative modifications in the effect on GnRH secretion. Serotonin (5-HT). GABA and catecholamines (CA) have qualitative differences in the effects on GnRH and LH secretion in early prepubertal than in late prepubertal and adult female rats. The administration of 5-hidroxytryptophan a precursor of serotonin (5-HT) which increases 5-HT hypothalamic levels induces GnRH and LH release in early prepubertal female rats. these effects disappear in late prepubertal stage having an inhibitory action in adult female rats. GABAereic system also stimulates GnRH and LH secretion in early prepubertal female rats and has an inhibitory action on this axis in late prepubertal period and in adult female rats. On the contrarythe inhibition of catecholamines synthesis by a-methyl-p-tyrosine induced an increase of LH secretion in early prepubertal female rats and inhibitoryeffect in late prepubertal and adult stage. These effects indicate tha CA has an inhibitory effects on GnRH-LH secretion in early prepubertal female rats changing to an stimulatory action in the late puberty and adult rats. These qualitative modifications were observed only in female rats and art: probably connected with the hypothalamic differentiation into a female typeof gonadotrophin control. Opiadergic and excitatory amino acid systems have quantitative differences on GnRH-LH secretion during prepubertal and peripubertal and adult stages. Opiates has an high inhibitory tone in early prepubertal rats that is decreasing during sexual maturation to reach puberty On the contrary EAA increases its stimulatory activity on GnRH-LH secretionduring sexual maturation by increasing the hypothalamic release of aspartate and glutamate. the excitatory amino acids involved in GnRH release. and the sensiti- bitity of NMDA receptors to these amino acids In conclusion sexual maturation and the onset of puberty in the female rats involve qualitative and quantitative modifications in the effects of neurotransmitters system on GnRH secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:27:41