Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SCH 58261 (an adenosine A(2A) receptor antagonist) reduces, only at low doses, K+-evoked glutamate release in the striatum
Autore:
Pintor, A; Quarta, D; Pezzola, A; Reggio, R; Popoli, P;
Indirizzi:
Ist Super Sanita, Dept Pharmacol, I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 Dept Pharmacol, I-00161 Rome, Italy
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 421, anno: 2001,
pagine: 177 - 180
SICI:
0014-2999(20010615)421:3<177:S5(AAR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR GLUTAMATE; NEUROLOGICAL DISORDERS; CEREBRAL-ISCHEMIA; NITRIC-OXIDE; AGED RATS; IN-VIVO; SCH-58261; BRAIN; NEUROPROTECTION; EXCITOTOXICITY;
Keywords:
SCH 58261; glutamate; striatum; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Popoli, P Ist Super Sanita, Dept Pharmacol, Viale Regina Elena 299, I-00161 Rome, Italy Ist Super Sanita Viale Regina Elena 299 Rome Italy I-00161 taly
Citazione:
A. Pintor et al., "SCH 58261 (an adenosine A(2A) receptor antagonist) reduces, only at low doses, K+-evoked glutamate release in the striatum", EUR J PHARM, 421(3), 2001, pp. 177-180

Abstract

The aim of the present work was to determine whether systemic administration of the adenosine Az, receptor antagonist, SCH 58261 (7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3,e]-1,2,4,triazolo[1,5,c]pyrimidine), couldmodulate striatal glutamate outflow in the rat. Microdialysis experiments were performed in male Wistar rats implanted with microdialysis probes in the striatum. Pretreatment (15 min before) with SCH 58261 (0.01 and 0.1, butnot 1 mg/kg intraperitoneally) significantly prevented K+-stimulated glutamate release. These results suggest that SCH 58261 could possess neuroprotective effects in the low dose range, while, at higher doses, the occurrenceof additional mechanisms may limit the neuroprotective potential of this drug. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 10:07:33