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Titolo:
Increased T cell expression of CD154 (CD40-ligand) in multiple sclerosis
Autore:
Jensen, J; Krakauer, M; Sellebjerg, F;
Indirizzi:
Univ Copenhagen, Glostrup Hosp, Dept Neurol, MS Clin, DK-2600 Glostrup, Denmark Univ Copenhagen Glostrup Denmark DK-2600 Clin, DK-2600 Glostrup, Denmark
Titolo Testata:
EUROPEAN JOURNAL OF NEUROLOGY
fascicolo: 4, volume: 8, anno: 2001,
pagine: 321 - 328
SICI:
1351-5101(200107)8:4<321:ITCEOC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD40 LIGAND; DISEASE-ACTIVITY; RHEUMATOID-ARTHRITIS; MESSENGER-RNA; PATHOGENESIS; LYMPHOCYTES; ACTIVATION;
Keywords:
CD154; CD40L; cerebrospinal fluid immunology; multiple sclerosis; optic neuritis; rheumatoid arthritis; T cell immunology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Jensen, J Univ Copenhagen, Glostrup Hosp, Dept Neurol, MS Clin, DK-2600 Glostrup, Denmark Univ Copenhagen Glostrup Denmark DK-2600 600 Glostrup, Denmark
Citazione:
J. Jensen et al., "Increased T cell expression of CD154 (CD40-ligand) in multiple sclerosis", EUR J NEUR, 8(4), 2001, pp. 321-328

Abstract

CD154 (CD40-ligand, gp39), expressed on activated T cells, is crucial in Tcell-dependent immune responses and may be involved in the pathogenesis ofmultiple sclerosis (MS). We studied cerebro-spinal fluid and peripheral blood T cell expression of CD 154 in MS by flow cytometry, Patients with secondary progressive MS (SPMS) had constitutive CD154 expression on CD4 and CD8 T cells in blood. Constitutive CD154 expression was not observed in patients with relapsing-remitting MS (RRMS) or clinically isolated syndromes (CIS) suggestive of demyelinating disease. After ex vivo activation CD154 was.however, expressed on a higher percentage of T cells from patients with CIS or RRMS than from healthy control subjects. These results suggest involvement of CD154 in the pathogenesis of MS, and the shift from a relapsing-remitting to a secondary progressive disease course may be associated with constitutive, systemic CD154 expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:56:32