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Titolo:
Lipid peroxidation in vivo is induced by exercise on a bicycle ergometer in athletes
Autore:
Wilson, R; Mansour, MR; Stewart, AD; Nimmo, IA; Shepherd, MJ; Riemersma, RA;
Indirizzi:
Univ Edinburgh, Dept Med, Cardiovasc Res Unit, Edinburgh EH8 9XF, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9XF Midlothian, Scotland Univ Aberdeen, Dept Biomed Sci, Aberdeen, Scotland Univ Aberdeen Aberdeen Scotland en, Dept Biomed Sci, Aberdeen, Scotland Univ Edinburgh, Dept Biomed Sci, Edinburgh, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland burgh, Midlothian, Scotland AFRC, Inst Food Res, Norwich NR4 7UA, Norfolk, England AFRC Norwich Norfolk England NR4 7UA s, Norwich NR4 7UA, Norfolk, England Univ Tromso, Dept Med Physiol, Tromso, Norway Univ Tromso Tromso NorwayUniv Tromso, Dept Med Physiol, Tromso, Norway
Titolo Testata:
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
fascicolo: 6, volume: 103, anno: 2001,
pagine: 350 - 354
SICI:
1438-7697(200106)103:6<350:LPIVII>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-E SUPPLEMENTATION; FREE-RADICALS; SKELETAL-MUSCLE; PLASMA; LIPOPROTEINS; OXIDATION; DAMAGE;
Keywords:
lipid peroxidation; exercise; vitamin C; gas chromatography; mass spectrometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Wilson, R Univ Edinburgh, Dept Med, Cardiovasc Res Unit, Hugh Robson Bldg,George Sq,Edinburgh EH8 9XF, Midlothian, Scotland Univ Edinburgh Hugh Robson Bldg,George Sq Edinburgh Midlothian Scotland EH8 9XF
Citazione:
R. Wilson et al., "Lipid peroxidation in vivo is induced by exercise on a bicycle ergometer in athletes", EUR J LIPID, 103(6), 2001, pp. 350-354

Abstract

There is a widely held belief that exercise leads to lipid peroxidation. Plasma hydroxy fatty acids originate from the diet and possibly from lipid peroxidation in vivo. We examined whether acute exercise (1 h at similar to 76% of predicted maximal aerobic capacity) leads to an increase in plasma hydroxy fatty acids without the confounding influence of the diet in 7 male athletes, In addition, using a random-sequence cross-over design, we examined whether vitamin C supplementation of 1 g per day for 10 days prior to exercise could prevent exercise-induced lipid peroxidation. Supplementation doubled the plasma vitamin C from 56.9 +/- 3.4 to 112.7 +/- 14.6 muM (P < 0.001) and lowered pre-exercise plasma hydroxy fatty acids from 1.30 <plus/minus> 0.18 to 1.03 +/- 0.14 muM (P < 0.05). Plasma hydroxyfatty acid levels rose up to 3-fold during exercise in some athletes on placebo and peak levels were reached after 20 min. The rise in plasma hydroxyfatty acid levels was delayed and remained lower after supplementation with vitamin C compared to placebo: 0.01 <plus/minus> 0.07 vs. 0.63 +/- 0.16 muM (P < 0.05), Vitamin C supplementation reduced pre-exercise creatine kinase levels (193 <plus/minus> 52 vs. 277 +/- 68 U/L; P < 0.05) but its effecton exercise-induced changes in creatine kinase did not reach statistical significance. In conclusion, large supplements of vitamin C reduced exercise-induced lipid peroxidation in athletes. This small, but carefully controlled study illustrates the usefulness of plasma hydroxy fatty acid levels to monitor lipid peroxidation in vivo in acute studies.

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Documento generato il 29/03/20 alle ore 15:25:39