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Titolo:
Samui, a novel cold-inducible gene, encoding a protein with a BAG domain similar to silencer of death domains (SODD/BAG-4), isolated from Bombyx diapause eggs
Autore:
Moribe, Y; Niimi, T; Yamashita, O; Yaginuma, T;
Indirizzi:
Nagoya Univ, Grad Sch Bioagr Sci, Lab Sericulture & Entomoresources, Chikusa Ku, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601a Ku, Nagoya, Aichi 4648601, Japan
Titolo Testata:
EUROPEAN JOURNAL OF BIOCHEMISTRY
fascicolo: 12, volume: 268, anno: 2001,
pagine: 3432 - 3442
SICI:
0014-2956(200106)268:12<3432:SANCGE>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMALIAN SORBITOL DEHYDROGENASE; ESCHERICHIA-COLI; LOW-TEMPERATURES; NONDIAPAUSE EGGS; SHOCK-PROTEIN; EXPRESSION; MORI; SILKWORM; DNA; HEAT;
Keywords:
cold-inducible gene; Samui; BAG domain; embryonic diapause; silkworm;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Yaginuma, T Nagoya Univ, Grad Sch Bioagr Sci, Lab Sericulture & Entomoresources, Chikusa Ku, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 , Aichi 4648601, Japan
Citazione:
Y. Moribe et al., "Samui, a novel cold-inducible gene, encoding a protein with a BAG domain similar to silencer of death domains (SODD/BAG-4), isolated from Bombyx diapause eggs", EUR J BIOCH, 268(12), 2001, pp. 3432-3442

Abstract

Cellular responses to cold-acclimation have not yet been studied in depth. To explore this field, we focussed on insect diapause development. Although embryonic diapause of Bombyx mori is sustained at 25 degreesC, chilling at 5 degreesC for 2 months causes diapause termination, a transition that ismarked when the sorbitol dehydrogenase gene (SDH) is activated. To clarifythe relationship between this activation and incubation at 5 degreesC, we isolated a novel cold-inducible gene, Samui. Expression of Samui mRNA and protein was activated after incubation at 5 degreesC for 5-6 days, lasted for another 30 days and then weakened. Exposure to 25 degreesC suppressed both mRNA and protein expression. In nondiapause eggs incubated at 5 degreesC,Samui was also up-regulated, although the expression was weaker. Samui contained nuclear localization-signals, a ssDNA-binding motif and a BAG domainsimilar to that of SODD/BAG-4. Because Samui could bind to HSP70, it is a member of BAG protein family. It is proposed that Samui serves to transmit the '5 degreesC signal' for SDH expression in diapause eggs, while also protecting against cold-injures in nondiapause eggs, through binding to respective partners. This is the first report that a member of BAG protein familyis up-regulated by cold.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:49:33