Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparative cognitive effects of carbamazepine and gabapentin in healthy senior adults
Autore:
Martin, R; Meador, K; Turrentine, L; Faught, E; Sinclair, K; Kuzniecky, R; Gilliam, F;
Indirizzi:
Univ Alabama, Dept Neurol, Epilepsy Ctr, CIRC 312, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 , CIRC 312, Birmingham, AL 35294 USA Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 Dept Neurol, Augusta, GA 30912 USA Univ Alabama, Dept Psychol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 pt Psychol, Birmingham, AL 35294 USA Washington Univ, Epilepsy Ctr, Dept Neurol, St Louis, MO USA Washington Univ St Louis MO USA lepsy Ctr, Dept Neurol, St Louis, MO USA
Titolo Testata:
EPILEPSIA
fascicolo: 6, volume: 42, anno: 2001,
pagine: 764 - 771
SICI:
0013-9580(200106)42:6<764:CCEOCA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELDERLY PATIENTS; DOUBLE-BLIND; EPILEPSY; PHENYTOIN; VALPROATE; MONOTHERAPY; MULTICENTER; LAMOTRIGINE; SEIZURES; BIPOLAR;
Keywords:
carbamazepine; gabapentin; cognition; mood; senior adults;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, R Univ Alabama, Dept Neurol, Epilepsy Ctr, CIRC 312, 1719 6th Ave S, Birmingham, AL 35294 USA Univ Alabama 1719 6th Ave S Birmingham AL USA 35294 AL 35294 USA
Citazione:
R. Martin et al., "Comparative cognitive effects of carbamazepine and gabapentin in healthy senior adults", EPILEPSIA, 42(6), 2001, pp. 764-771

Abstract

Purpose: This study compared the cognitive effects of carbamazepine (CBZ) and gabapentin (GBP) in healthy senior adults by using a randomized, double-blind crossover design. Methods: Thirty-four senior adults were randomized to receive one of the two drugs followed by a 5-week treatment period. A 4-week washout phase preceded initiation of the second drug. Antiepileptic drugs (AEDs) were titrated to target doses of either CBZ (800 mg/day) or GBP (2.400 mg/day). Primaryoutcome measures were standardized neuropsychological tests of attention/vigilance, psychomotor speed, motor speed, verbal and visual memory, and theprofile of Mood State (POMS), yielding a total of 17 variables. Each subject received cognitive testing at predrug baseline, end of first drug phase,end of second drug phase, and 4 weeks after completion of the second drug phase. Results: Fifteen senior adults (mean ape, 66.5 years: range. 59-76 years) completed the study. Seniors completing the study did not differ significantly from noncompleting seniors in terms of demographic features or baselinecognitive performances. Fifteen of the 19 seniors not completing the studydropped our while receiving CBZ, Adverse events were frequently reported for both AEDs, although they were more common for CBZ. Mean serum levels forthe completers were within midrange clinical doses (CBZ, 6.8 mug/ml; GBP, 7.1 mug/ml). Significant differences between CBZ and GBP were found for only one of 11 cognitive variables, with better attention/vigilance for GBP, although the effect was modest. Performances on the nondrug average were significantly better on 45% of cognitive variables compared with CBZ and 36% compared with GBP. The overall pattern of means favored GBP over CBZ on 15 of 17 (p < 0.001), nondrug over CBZ on 17 of 17 (p < 0.0000), and nondrug over GBP on eight of 17 (NS). Conclusions: Mild cognitive effects were found for both AEDs compared withthe nondrug average condition. The magnitude of difference between the twoAEDs across the cognitive variables was modest. Self-reported mood was notsignificantly affected by either AED. However, overall tolerability and side-effect profile of CBZ were poorer than those of GBP in senior adults at doses and titration rates reported in this study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:44:05