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Titolo:
A putative GDP-GTP exchange factor is required for development of the excretory cell in Caenorhabditis elegans
Autore:
Suzuki, N; Buechner, M; Nishiwaki, K; Hall, DH; Nakanishi, H; Takai, Y; Hisamoto, N; Matsumoto, K;
Indirizzi:
Nagoya Univ, Grad Sch Sci, Dept Mol Biol, Chikusa Ku, Nagoya, Aichi 4648602, Japan Nagoya Univ Nagoya Aichi Japan 4648602 a Ku, Nagoya, Aichi 4648602, Japan Japan Sci & Technol Corp, CREST, Chikusa Ku, Nagoya, Aichi 4648602, Japan Japan Sci & Technol Corp Nagoya Aichi Japan 4648602 Aichi 4648602, Japan NEC Corp Ltd, Fundamental Res Labs, Tsukuba, Ibaraki 3058501, Japan NEC Corp Ltd Tsukuba Ibaraki Japan 3058501 sukuba, Ibaraki 3058501, Japan Japan Sci & Technol Corp, PRESTO, Tsukuba, Ibaraki 3058501, Japan Japan Sci & Technol Corp Tsukuba Ibaraki Japan 3058501 aki 3058501, Japan Osaka Univ, Sch Med, Dept Mol Biol & Biochem, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Biochem, Suita, Osaka 5650871, Japan Univ Kansas, Dept Mol Biosci, Lawrence, KS 66045 USA Univ Kansas LawrenceKS USA 66045 Dept Mol Biosci, Lawrence, KS 66045 USA Yeshiva Univ Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 nx, NY 10461 USA
Titolo Testata:
EMBO REPORTS
fascicolo: 6, volume: 2, anno: 2001,
pagine: 530 - 535
SICI:
1469-221X(200106)2:6<530:APGEFI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIN CYTOSKELETON; BINDING PROTEIN; C-ELEGANS; GENE; FAMILY; KINASE; SYSTEM; FGD1; ACTIVATION; MIGRATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Matsumoto, K Nagoya Univ, Grad Sch Sci, Dept Mol Biol, Chikusa Ku, Nagoya,Aichi 4648602, Japan Nagoya Univ Nagoya Aichi Japan 4648602 Aichi 4648602, Japan
Citazione:
N. Suzuki et al., "A putative GDP-GTP exchange factor is required for development of the excretory cell in Caenorhabditis elegans", EMBO REP, 2(6), 2001, pp. 530-535

Abstract

The Caenorhabditis elegans excretory cell extends tubular processes, called canals, along the basolateral surface of the epidermis. Mutations in the exc-5 gene cause tubulocystic defects in this canal. Ultrastructural analysis suggests that exc-5 is required for the proper placement of cytoskeletalelements at the apical epithelial surface. exc-5 encodes a protein homologous to guanine nucleotide exchange factors and contains motif architecture similar to that of FGD1, which is responsible for faciogenital dysplasia. exc-5 interacts genetically with mig-2 which encodes Rho GTPase. These results suggest that EXC-5 controls the structural organization of the excretorycanal by regulating Rho family GTPase activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:09:49