Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans
Autore:
Wang, P; Cardenas, ME; Cox, CM; Perfect, JR; Heitman, J;
Indirizzi:
Duke Univ, Med Ctr, Dept Genet, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 , Med Ctr, Dept Genet, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 iv, Med Ctr, Dept Med, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Microbiol, Durham, NC 27710 USA Duke Univ DurhamNC USA 27710 d Ctr, Dept Microbiol, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 oward Hughes Med Inst, Durham, NC 27710 USA
Titolo Testata:
EMBO REPORTS
fascicolo: 6, volume: 2, anno: 2001,
pagine: 511 - 518
SICI:
1469-221X(200106)2:6<511:TCAHWS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLOSPORINE-A; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTION FACTOR; SIGNAL-TRANSDUCTION; GENE-EXPRESSION; CALCINEURIN; YEAST; INHIBITION; FK506; MECHANISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Heitman, J Duke Univ, Med Ctr, Dept Genet, 322 CARL Bldg,Res Dr, Durham, NC 27710 USA Duke Univ 322 CARL Bldg,Res Dr Durham NC USA 27710 NC 27710 USA
Citazione:
P. Wang et al., "Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans", EMBO REP, 2(6), 2001, pp. 511-518

Abstract

Cyclophilin A is the target of the immunosuppressant cyclosporin A (CsA) and is encoded by a single unique gene conserved from yeast to humans. In the pathogenic fungus Cryptococcus neoformans, two homologous linked genes, CPA1 and CPA2, were found to encode two conserved cyclophilin A proteins. Incontrast to Saccharomyces cerevisiae, in which cyclophilin A mutations confer CsA resistance but few other phenotypes, cyclophilin A mutations conferred dramatic phenotypes in C. neoformans. The Cpa1 and Cpa2 cyclophilin A proteins play a shared role in cell growth, mating, virulence and CsA toxicity. The Cpa1 and Cpa2 proteins also have divergent functions. cpa1 mutants are inviable at 39 degreesC and attenuated for virulence, whereas cpa2 mutants are viable at 39 degreesC and fully virulent. cpa1 cpa2 double mutants exhibited synthetic defects in growth and virulence. Cyclophilin A active site mutants restored growth of cpa1 cpa2 mutants at ambient but not at higher temperatures, suggesting that the prolyl isomerase activity of cyclophilin A has an in vivo function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 06:24:29