Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Thyroid hormone regulates the obesity gene tub
Autore:
Kortischoner, NP; Alvarez-Dolado, M; Kurz, SM; Heikenwalder, MF; Hacker, C; Vogel, F; Munoz, A; Zenke, M;
Indirizzi:
Max Delbruck Ctr Mol Med MDC, D-13122 Berlin, Germany Max Delbruck Ctr MolMed MDC Berlin Germany D-13122 3122 Berlin, Germany Univ Autonoma Madrid, CSIC, Inst Invest Biomed Alberto Sols, E-28029 Madrid, Spain Univ Autonoma Madrid Madrid Spain E-28029 to Sols, E-28029 Madrid, Spain
Titolo Testata:
EMBO REPORTS
fascicolo: 6, volume: 2, anno: 2001,
pagine: 499 - 504
SICI:
1469-221X(200106)2:6<499:THRTOG>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MOLECULAR CHARACTERIZATION; TRANSCRIPTION FACTORS; RAT-BRAIN; C-ERBA; RECEPTOR; MOUSE; EXPRESSION; DIFFERENTIATION; THERMOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Zenke, M Max Delbruck Ctr Mol Med MDC, Robert Rossle Str 10, D-13122 Berlin, Germany Max Delbruck Ctr Mol Med MDC Robert Rossle Str 10 Berlin Germany D-13122
Citazione:
N.P. Kortischoner et al., "Thyroid hormone regulates the obesity gene tub", EMBO REP, 2(6), 2001, pp. 499-504

Abstract

Thyroid hormone T3/T4 is a major regulator of energy metabolism in vertebrates, and defects in thyroid status are frequently associated with changes in body weight. It is demonstrated here that thyroid hormone regulates in vivo and in vitro the tub gene, which when mutated in tubby mice causes obesity, insulin resistance and sensory deficits. Hypothyroidism in rats altered tub mRNA and protein in discrete brain areas. These changes could be attributed to thyroid hormone deficiency since T3/T4 treatment restored normal tub expression. T3 also upregulated tub mRNA within 4-6 h in neuronal cellsin culture, suggesting that T3 is a positive regulator of tub gene expression. Thus, these results establish a novel pathway of T3 action and providean important molecular link between thyroid status and the tubby-associated syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 22:03:40