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Titolo:
Secured cutting: controlling separase at the metaphase to anaphase transition
Autore:
Uhlmann, F;
Indirizzi:
Imperial Canc Res Fund, London WC2A 3PX, England Imperial Canc Res Fund London England WC2A 3PX London WC2A 3PX, England
Titolo Testata:
EMBO REPORTS
fascicolo: 6, volume: 2, anno: 2001,
pagine: 487 - 492
SICI:
1469-221X(200106)2:6<487:SCCSAT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SISTER-CHROMATID SEPARATION; DNA-DAMAGE CHECKPOINT; SACCHAROMYCES-CEREVISIAE; FISSION YEAST; BUDDING YEAST; CHROMOSOME MISSEGREGATION; COHESIN COMPLEXES; CUT2 PROTEOLYSIS; PROTEIN; SPINDLE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Uhlmann, F Imperial Canc Res Fund, 44 Lincolns Inn Fields, London WC2A 3PX, England Imperial Canc Res Fund 44 Lincolns Inn Fields London England WC2A 3PX
Citazione:
F. Uhlmann, "Secured cutting: controlling separase at the metaphase to anaphase transition", EMBO REP, 2(6), 2001, pp. 487-492

Abstract

The final irreversible step in the duplication and distribution of genomesto daughter cells takes place at the metaphase to anaphase transition. At this point aligned sister chromatid pairs split and separate. During metaphase, cohesion between sister chromatids is maintained by the chromosomal multi-subunit cohesin complex. Here, I review recent findings as to how anaphase is initiated by proteolytic cleavage of the Scc1 subunit of cohesin. Scc1 is cleaved by a site-specific protease that is conserved in all eukaryotes, and is now called 'separase'. As a result of this cleavage, the cohesincomplex is destroyed, allowing the spindle to pull sister chromatids into opposite halves of the cell. Because of the final and irreversible nature of Scc1 cleavage, this reaction is tightly controlled. Several independent mechanisms seem to impose regulation on Scc1 cleavage, acting on both the activity of separase and the susceptibility of the substrate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:20:47