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Titolo:
The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN,the American Diabetes Association and the German Diabetes Society
Autore:
Rosen, P; Nawroth, PP; King, G; Moller, W; Tritschler, HJ; Packer, L;
Indirizzi:
Diabet Forschungsinst, D-40250 Dusseldorf, Germany Diabet Forschungsinst Dusseldorf Germany D-40250 250 Dusseldorf, Germany Univ Tubingen, Med Klin, D-7400 Tubingen, Germany Univ Tubingen TubingenGermany D-7400 Med Klin, D-7400 Tubingen, Germany Joslin Diabet Ctr, Boston, MA 02215 USA Joslin Diabet Ctr Boston MA USA 02215 in Diabet Ctr, Boston, MA 02215 USA ASTA Med, Frankfurt, Germany ASTA Med Frankfurt GermanyASTA Med, Frankfurt, Germany Univ Calif Berkeley, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 erkeley, Berkeley, CA 94720 USA
Titolo Testata:
DIABETES-METABOLISM RESEARCH AND REVIEWS
fascicolo: 3, volume: 17, anno: 2001,
pagine: 189 - 212
SICI:
1520-7552(200105/06)17:3<189:TROOSI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; ALPHA-LIPOIC ACID; LOW-DENSITY-LIPOPROTEIN; ENDOTHELIAL GROWTH-FACTOR; GLYCATION END-PRODUCTS; RANDOMIZED CONTROLLED TRIAL; IMPAIRED GLUCOSE-TOLERANCE; GLOMERULAR MESANGIAL CELLS; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B;
Keywords:
oxidative stress; diabetes mellitus; vascular complications; neuropathy; insulin resistance;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
305
Recensione:
Indirizzi per estratti:
Indirizzo: Rosen, P Diabet Forschungsinst, Hennekamp 65, D-40250 Dusseldorf, Germany Diabet Forschungsinst Hennekamp 65 Dusseldorf Germany D-40250 ny
Citazione:
P. Rosen et al., "The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN,the American Diabetes Association and the German Diabetes Society", DIABET M R, 17(3), 2001, pp. 189-212

Abstract

This review summarises the results and discussions of an UNESCO-MCBN supported symposium on oxidative stress and its role in the onset and progression of diabetes. There is convincing experimental and clinical evidence that the generation of reactive oxygen species (ROI) is increased in both types of diabetes and that the onset of diabetes is closely associated with oxidative stress. Nevertheless there is controversy about which markers of oxidative stress are most reliable and suitable for clinical practice. There arevarious mechanisms that contribute to the formation of ROI. It is generally accepted that vascular cells and especially the endothelium become one major source of ROI. An important role of oxidative stress for the development of vascular and neurological complications is suggested by experimental and clinical studies. The precise mechanisms by which oxidative stress may accelerate the development of complications in diabetes are only partly known. There is however evidence for a role of protein kinase C, advanced glycation end products (AGE) and activation of transcription factors such as NF kappaB, but the exact signalling pathways and the interactions with ROI remain a matter of discussion. Additionally, results of very recent studies suggest a role for ROI in the development of insulin resistance. ROI interfere with insulin signalling at various levels and are able to inhibit the translocation of GLUT4 in the plasma membrane. Evidence for a protective effect of antioxidants has been presented in experimental studies, but conclusive evidence from patient studies is missing. Large-scale clinical trials such as the DCCT Study or the UKPDS Study are needed to evaluate the long-termeffects of antioxidants in diabetic patients and their potential to reducethe medical and socio-economic burden of diabetes and its complications. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:15:03