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Titolo:
Prevalence of clinical and isolated subclinical cardiovascular disease in older adults with glucose disorders - The Cardiovascular Health Study
Autore:
Barzilay, JI; Spiekerman, CF; Kuller, LH; Burke, GL; Bittner, V; Gottdiener, JS; Brancati, FL; Orchard, TJ; OLeary, DH; Savage, PJ;
Indirizzi:
Kaiser Permanente Georgia, Div Endocrinol, Tucker, GA 30084 USA Kaiser Permanente Georgia Tucker GA USA 30084 rinol, Tucker, GA 30084 USA Emory Univ, Sch Med, Div Endocrinol, Atlanta, GA USA Emory Univ Atlanta GA USA Univ, Sch Med, Div Endocrinol, Atlanta, GA USA Univ Washington, Dept Biostat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biostat, Seattle, WA 98195 USA Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA th, Dept Epidemiol, Pittsburgh, PA USA Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27103 USA Wake Forest Univ Winston Salem NC USA 27103 , Winston Salem, NC 27103 USA Univ Alabama, Dept Cardiovasc Dis, Birmingham, AL USA Univ Alabama Birmingham AL USA , Dept Cardiovasc Dis, Birmingham, AL USA St Francis Hosp, Dept Cardiol, Roslyn, NY USA St Francis Hosp Roslyn NY USA Francis Hosp, Dept Cardiol, Roslyn, NY USA Johns Hopkins Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD USA JohnsHopkins Sch Hyg & Publ Hlth Baltimore MD USA ol, Baltimore, MD USA Tufts Univ, New England Med Ctr, Dept Radiol, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 Med Ctr, Dept Radiol, Boston, MA 02111 USA NHLBI, Div Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 & Clin Applicat, NIH, Bethesda, MD 20892 USA
Titolo Testata:
DIABETES CARE
fascicolo: 7, volume: 24, anno: 2001,
pagine: 1233 - 1239
SICI:
0149-5992(200107)24:7<1233:POCAIS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANKLE-ARM INDEX; DIABETES-MELLITUS; RISK FACTOR; MYOCARDIAL-INFARCTION; ARTERY DISEASE; ATHEROSCLEROSIS; ASSOCIATION; MORTALITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Barzilay, JI Kaiser Permanente Georgia, Div Endocrinol, 200 Crescent Ctr Pkwy, Tucker, GA 30084 USA Kaiser Permanente Georgia 200 Crescent Ctr Pkwy Tucker GA USA 30084
Citazione:
J.I. Barzilay et al., "Prevalence of clinical and isolated subclinical cardiovascular disease in older adults with glucose disorders - The Cardiovascular Health Study", DIABET CARE, 24(7), 2001, pp. 1233-1239

Abstract

OBJECTIVE - Clinical cardiovascular disease (CVD) is highly prevalent among people with diabetes. However, there is little information regarding the prevalence of subclinical CVD and its relation to clinical CVD in diabetes and in the glucose disorders that precede diabetes. RESEARCH DESIGN AND METHODS - Participants in the Cardiovascular Health Study, aged greater than or equal to 65 years (n = 5,888), underwent vascularand metabolic testing. Individuals with known disease in the coronary, cerebral, or peripheral circulations were considered to have clinical disease. Those without any clinical disease in whom CVD was detected by ultrasonography, electrocardiography, or ankle arm index in any of the three vascular beds were considered to have isolated subclinical disease. RESULTS - Approximately 30% of the cohort had clinical disease, and similar to 60% of the remainder had isolated subclinical disease. In those with normal glucose status, isolated subclinical disease made up most of the total CVD. With increasing glucose severity, the proportion of total CVD that was clinical disease increased; 75% of men and 66% of women with normal fasting glucose status had either clinical or subclinical CVD. Among those withknown diabetes, the prevalence was similar to 88% (odds ratio [OR] 2.46 for men and 4.22 for women, P < 0.0001). There were intermediate prevalences and ORs for those with impaired fasting glucose status and newly diagnosed diabetes. CONCLUSIONS - Isolated subclinical CVD is common among older adults. Glucose disorders are associated with an increased prevalence of total CVD and an increased proportion of clinical disease relative to subclinical disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 08:57:47