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Titolo:
Diabetes and risk of fracture - The Blue Mountains Eye Study
Autore:
Ivers, RQ; Cumming, RG; Mitchell, P; Peduto, AJ;
Indirizzi:
Inst Int Hlth, Newtown, NSW 2042, Australia Inst Int Hlth Newtown NSW Australia 2042 th, Newtown, NSW 2042, Australia Univ Sydney, Dept Publ Hlth & Community Med, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ty Med, Sydney, NSW 2006, Australia Univ Sydney, Westmead Hosp, Dept Ophthalmol, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 halmol, Sydney, NSW 2006, Australia
Titolo Testata:
DIABETES CARE
fascicolo: 7, volume: 24, anno: 2001,
pagine: 1198 - 1203
SICI:
0149-5992(200107)24:7<1198:DAROF->2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MINERAL DENSITY; AGE-RELATED CATARACT; BEAVER DAM EYE; HIP FRACTURE; VISUAL-ACUITY; OLDER WOMEN; WHITE WOMEN; MELLITUS; AUSTRALIA; MASS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Ivers, RQ Inst Int Hlth, POB 576, Newtown, NSW 2042, Australia Inst Int Hlth POB 576 Newtown NSW Australia 2042 2042, Australia
Citazione:
R.Q. Ivers et al., "Diabetes and risk of fracture - The Blue Mountains Eye Study", DIABET CARE, 24(7), 2001, pp. 1198-1203

Abstract

OBJECTIVE - To examine associations between measures of diabetes and risk of fracture in a population-based sample of older Australians. RESEARCH DESIGN AND METHODS - This was a prospective study of 3,654 subjects aged 49 years and older who were residents in the Blue Mountains, west of Sydney, Australia. At baseline, subjects were asked questions about history and treatment of diabetes, and fasting blood samples were taken. Photographs were taken of the retina and lens to grade retinopathy and cataract. Details of fractures (excluding rib and vertebral fractures) were collected by a combination of self-report and medical record searches; all fractures were radiologically confirmed. RESULTS - After 2 years of follow-up, we found that several diabetes-related factors were significantly associated (in multivariate models) with increased risk of all fractures combined, including presence of diabetic retinopathy (adjusted RR 5.4, 95% CI 2.7-10.8), diabetes duration greater than orequal to 10 years (3.3, 1.3-8.2), cortical cataract involving greater thanor equal to 25% of the lens area (2.5, 1.3-4.7), and insulin treatment (5.9, 2.6-13.5). The proximal humerus was the only individual fracture site associated with diabetes. Diabetic retinopathy (10.3, 2.2-48.0), diabetes duration (for greater than or equal to 10 years duration; 11.4, 2.4-54.2), andinsulin treatment(18.8, 4.0-88.7) were all associated with proximal humerus fracture. CONCLUSIONS - These data suggest a significantly increased risk of fracture associated with diabetic retinopathy, advanced cortical cataract, longer diabetes duration, and insulin treatment. However, there are some shortcomings in this study that may limit these findings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:43:11