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Titolo:
Following direct CD40 activation, human primary microglial cells produce IL-12 p40 but not bioactive IL-12 p70
Autore:
de Herve, MGD; Delfraissy, JF; Taoufik, Y;
Indirizzi:
Univ Paris 11, Lab Virus Neurone & Immun, Paris, France Univ Paris 11 Paris France 11, Lab Virus Neurone & Immun, Paris, France Univ Paris 11, Immunol Lab, Paris, France Univ Paris 11 Paris FranceUniv Paris 11, Immunol Lab, Paris, France CHU Bicetre, Bicetre, France CHU Bicetre Bicetre FranceCHU Bicetre, Bicetre, France
Titolo Testata:
CYTOKINE
fascicolo: 2, volume: 14, anno: 2001,
pagine: 88 - 96
SICI:
1043-4666(20010421)14:2<88:FDCAHP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD40-CD40 LIGAND INTERACTION; CENTRAL-NERVOUS-SYSTEM; ANTIGEN PRESENTATION; INTERFERON-GAMMA; INTERLEUKIN-12 PRODUCTION; MULTIPLE-SCLEROSIS; T-CELLS; TH1; ENCEPHALOMYELITIS; MACROPHAGES;
Keywords:
microglial cells; CD40; IL-12;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Taoufik, Y Hop Bicetre, Immunol Lab, Hematol Serv, 78 Rue Gen Leclerc, F-94270 Le Kremlin Bicetre, France Hop Bicetre 78 Rue Gen Leclerc Le Kremlin Bicetre France F-94270
Citazione:
M.G.D. de Herve et al., "Following direct CD40 activation, human primary microglial cells produce IL-12 p40 but not bioactive IL-12 p70", CYTOKINE, 14(2), 2001, pp. 88-96

Abstract

There is accumulating evidence that interleukin 12 (IL-12) is involved in the pathogenesis of multiple sclerosis, In the periphery, this cytokine is produced by antigen-presenting cells (APCs) following interaction with activated T cells, CD40 ligation plays a crucial role in this production. Microglial cells are thought to play a major role in antigen presentation in thecentral nervous system. In this work, we examined IL-12 production by human primary microglial cells after CD40 ligation, These cells expressed CD40 and MHC class II following interferon-gamma activation. IL-12 p40 mRNA and protein, but not bioactive IL-12 p70, were detected in response to direct CD40 activation. Microglial cells co-cultured with activated allogenic CD4+ T lymphocytes also produced IL-12 p40 but not IL-12 p70, This IL-12 p40 production was inhibited by anti-CD40 ligand, Altogether, these results suggest that CD40-CD40-ligand interaction provides a signal that triggers IL-12 p40 expression. However, other interaction(s) may be required during antigenpresentation for bioactive heterodimeric IL-12 p70 to be produced by microglial cells. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:13:17