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Titolo:
Signaling domains of the interleukin 2 receptor
Autore:
Gaffen, SL;
Indirizzi:
SUNY Buffalo, Dept Oral Biol, Sch Dent Med, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 ol, Sch Dent Med, Buffalo, NY 14214 USA SUNY Buffalo, Dept Microbiol, Sch Med & Biomed Sci, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 Med & Biomed Sci, Buffalo, NY 14214 USA
Titolo Testata:
CYTOKINE
fascicolo: 2, volume: 14, anno: 2001,
pagine: 63 - 77
SICI:
1043-4666(20010421)14:2<63:SDOTI2>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL PROLIFERATION; SEVERE COMBINED IMMUNODEFICIENCY; DEFECTIVE LYMPHOID DEVELOPMENT; TRANSDUCING ADAPTER MOLECULE; PROTEIN-TYROSINE KINASES; MEMBRANE-PROXIMAL REGION; GAMMA CHAIN GAMMA(C); HUMAN IL-2 RECEPTOR; JAK-3 JANUS KINASE; MICE LACKING JAK3;
Keywords:
autoimmunity; cytokine; interleukin 2; receptor; signal transduction;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
188
Recensione:
Indirizzi per estratti:
Indirizzo: Gaffen, SL SUNY Buffalo, Dept Oral Biol, Sch Dent Med, 36 Foster Hall,3435Main St, Buffalo, NY 14214 USA SUNY Buffalo 36 Foster Hall,3435 Main St Buffalo NY USA 14214 A
Citazione:
S.L. Gaffen, "Signaling domains of the interleukin 2 receptor", CYTOKINE, 14(2), 2001, pp. 63-77

Abstract

Interleukin (IL-)2 and its receptor (IL-2R) constitute one of the most extensively studied cytokine receptor systems. IL-2 is produced primarily by activated T cells and is involved in early T cell activation as well as in maintaining homeostatic immune responses that prevent autoimmunity. This review focuses on molecular signaling pathways triggered by the IL-2/IL-2R complex, with an emphasis on how the IL-2R physically translates its interaction with IL-2 into a coherent biological outcome. The IL-2R is composed of three subunits, IL-2R alpha, IL-2R beta and gammac, Although IL-2R alpha is an important affinity modulator that is essential for proper responses in vivo, it does not contribute to signaling due a short cytoplasmic tail. In contrast, IL-2R beta and gammac together are necessary and sufficient for effective signal transduction, and they serve physically to connect the receptor complex to cytoplasmic signaling intermediates. Despite an absolute requirement for gammac in signaling, the majority of known pathways physicallylink to the receptor via IL-2R beta, generally through phosphorylated cytoplasmic tyrosine residues. This review highlights work performed both in cultured cells and in vivo that defines the functional contributions of specific receptor subdomains-and, by inference, the specific signaling pathways that they activate-to IL-2-dependent biological activities. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:34:57