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Titolo:
Acute chest syndrome of sickle cell disease: new light on an old problem
Autore:
Stuart, MJ; Setty, BNY;
Indirizzi:
Thomas Jefferson Univ, Jefferson Med Coll, Dept Pediat, Div Res Hematol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA Thomas Jefferson Univ, Cardeza Fdn Hematol Res, Philadelphia, PA 19107 USAThomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA
Titolo Testata:
CURRENT OPINION IN HEMATOLOGY
fascicolo: 2, volume: 8, anno: 2001,
pagine: 111 - 122
SICI:
1065-6251(200103)8:2<111:ACSOSC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHALED NITRIC-OXIDE; HYPOXIC PULMONARY VASOCONSTRICTION; HUMAN-ENDOTHELIAL-CELLS; ERYTHROCYTE PHOSPHATIDYLSERINE EXPOSURE; ACUTE LUNG INJURY; S-NITROSOHEMOGLOBIN; POTENTIAL ROLE; MICROVASCULAR ENDOTHELIUM; VASCULAR ENDOTHELIUM; OXYGEN-AFFINITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
119
Recensione:
Indirizzi per estratti:
Indirizzo: Stuart, MJ Thomas Jefferson Univ, Jefferson Med Coll, Dept Pediat, Div ResHematol, 1025 Walnut St,Suite 727, Philadelphia, PA 19107 USA Thomas Jefferson Univ 1025 Walnut St,Suite 727 Philadelphia PA USA 19107
Citazione:
M.J. Stuart e B.N.Y. Setty, "Acute chest syndrome of sickle cell disease: new light on an old problem", CURR OPIN H, 8(2), 2001, pp. 111-122

Abstract

The pulmonary findings of acute chest syndrome of sickle cell disease havebeen well characterized in numerous studies. Whereas a third of patients have a documented infection associated with this syndrome, and fat embolism from necrotic marrow is the etiologic factor in another approximately 10%. no cause is discovered in the majority of patients. In most patients, however, the underlying pathophysiology is the presence of a hypoxia-driven, adhesion-related occlusive event in the pulmonary microcirculation. This may be accompanied by a decrease in the levels of normal cytoprotective and anti-adhesive mediators such as nitric oxide. In the patient with sickle cell disease, the lung is also a uniquely vulnerable target organ because its vasculature constricts with hypoxia in contrast to other vascular beds. This review will establish the links between known etiologic agents and the pathophysiology of this syndrome. An additional section of this review will dealwith experimental therapies. The use of inhaled nitric oxide will be explored in depth because advances in this area are current and uniquely relevant to acute chest syndrome. (C) 2001 Lippincott Williams & Wilkins, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:12:16