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Titolo:
Exercise and interleukin-6
Autore:
Pedersen, BK; Steensberg, A; Schjerling, P;
Indirizzi:
Univ Copenhagen, Rigshosp, Dept Infect Dis M7641, DK-2200 Copenhagen N, Denmark Univ Copenhagen Copenhagen Denmark N 7641, DK-2200 Copenhagen N, Denmark Univ Copenhagen, Rigshosp, Copenhagen Muscle Res Ctr, DK-2200 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2200 , DK-2200 Copenhagen, Denmark
Titolo Testata:
CURRENT OPINION IN HEMATOLOGY
fascicolo: 3, volume: 8, anno: 2001,
pagine: 137 - 141
SICI:
1065-6251(200105)8:3<137:EAI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; STRENUOUS EXERCISE; ECCENTRIC EXERCISE; CYTOKINE RESPONSE; IMMUNE-SYSTEM; TNF-ALPHA; PLASMA INTERLEUKIN-6; INTENSE EXERCISE; INDUCED INCREASE; HUMAN MYOBLASTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Pedersen, BK Univ Copenhagen, Rigshosp, Dept Infect Dis M7641, Tagensvej 20, DK-2200 Copenhagen N, Denmark Univ Copenhagen Tagensvej 20 Copenhagen Denmark N N, Denmark
Citazione:
B.K. Pedersen et al., "Exercise and interleukin-6", CURR OPIN H, 8(3), 2001, pp. 137-141

Abstract

Strenuous exercise induces increased levels in a number of pro- and anti-inflammatory cytokines, natural occurring cytokine inhibitors, and chemokines. Thus, increased plasma levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-1 receptor antagonist (IL-1 ra), TNF-receptors (TNF-R), IL-10, IL-8, and macrophage inflammatory protein (MIP)-1 are found after strenuous exercise. The concentration of IL-8 increases as much as 100-fold after a marathon race. It has recently been demonstrated that IL-6 is produced locally in contracting skeletal muscles and that the net release from the muscle can account for the exercise-induced increase in arterial concentration. Larger amounts of IL-6 are produced in response to exercise than any other cytokine, IL-6 is produced locally in the skeletal muscle in response to exercise, and IL-6 is known to induce hepatic glucose output and to induce lipolysis. These facts indicate that IL-6 may represent an important link between contracting skeletal muscles and exercise-related metabolic changes. (C) 2001 Lippincott Williams & Wilkins, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:14:57