Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mechanisms of tissue damage in inflammatory bowel disease
Autore:
Pallone, F; Monteleone, G;
Indirizzi:
Univ Roma Tor Vergata, Dipartimento Med Interna, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 ed Interna, I-00133 Rome, Italy
Titolo Testata:
CURRENT OPINION IN GASTROENTEROLOGY
fascicolo: 4, volume: 17, anno: 2001,
pagine: 307 - 312
SICI:
0267-1379(200107)17:4<307:MOTDII>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC INTESTINAL INFLAMMATION; TRANSFORMING-GROWTH-FACTOR; RECEPTOR BETA-2 CHAIN; CROHNS-DISEASE; ULCERATIVE-COLITIS; T-CELLS; INTERFERON-GAMMA; IMMUNOGLOBULIN-G; CYTOSKELETAL PROTEIN; INTERLEUKIN-12;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Pallone, F Univ Roma Tor Vergata, Dipartimento Med Interna, Via Tor Vergata 135, I-00133 Rome, Italy Univ Roma Tor Vergata Via Tor Vergata 135 Rome Italy I-00133 y
Citazione:
F. Pallone e G. Monteleone, "Mechanisms of tissue damage in inflammatory bowel disease", CURR OPIN G, 17(4), 2001, pp. 307-312

Abstract

Crohn disease and ulcerative colitis are caused by an excessive immune-inflammatory reaction in the intestinal wall. Analysis of the types of immune response ongoing in the inflamed intestine has revealed that in Crohn disease there is predominantly a T helper cell type 1 response, with exaggeratedproduction of interleukin (IL)-12 and interferon-gamma, whereas in ulcerative colitis the lesion seems to be more of an antibody-mediated hypersensitivity reaction. Despite these differences, downstream inflammatory events are probably similar in both conditions. In both Crohn disease and ulcerative colitis there is an increased synthesis of proinflammatory cytokines, including IL-1 beta, IL-6, IL-8, IL-16, and tumor necrosis factor-alpha accompanying the influx of nonspecific inflammatory cells into the mucosa, These cytokines contribute to the tissue damage either directly or indirectly by enhancing the production of matrix metalloproteinases and growth factors, which produce ulceration as well as mucosal repair.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:40:46