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Titolo:
Glucose-dependent insulinotropic polypeptide (GIP) and the enteroinsular axis in equines (Equus caballus)
Autore:
Duhlmeier, R; Deegen, E; Fuhrmann, H; Widdel, A; Sallmann, HP;
Indirizzi:
Inst Physiol Chem, D-30559 Hannover, Germany Inst Physiol Chem Hannover Germany D-30559 em, D-30559 Hannover, Germany Tierarztlichen Hsch Hannover, Klin Pferde, D-30559 Hannover, Germany Tierarztlichen Hsch Hannover Hannover Germany D-30559 Hannover, Germany Univ Leipzig, Fak Vet Med, Vet Physiol Chem Inst, D-7010 Leipzig, Germany Univ Leipzig Leipzig Germany D-7010 l Chem Inst, D-7010 Leipzig, Germany
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 2-3, volume: 129, anno: 2001,
pagine: 563 - 575
SICI:
1095-6433(200106)129:2-3<563:GIP(AT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-INHIBITORY POLYPEPTIDE; GLUCAGON-LIKE PEPTIDE-1(7-36)AMIDE; LIPOPROTEIN-LIPASE ACTIVITY; RAT ADIPOSE-TISSUE; TOLERANCE TEST; INTRAVENOUS GLUCOSE; LIPID-METABOLISM; SECRETION; HORSES; PONIES;
Keywords:
enteroinsular axis; glucose-dependent insulinotropic polypeptide; radioimmunoassay; glucose; glucose tolerance test; insulin; large horse; pony;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Sallmann, HP Inst Physiol Chem, Bunteweg 17, D-30559 Hannover, Germany Inst Physiol Chem Bunteweg 17 Hannover Germany D-30559 rmany
Citazione:
R. Duhlmeier et al., "Glucose-dependent insulinotropic polypeptide (GIP) and the enteroinsular axis in equines (Equus caballus)", COMP BIOC A, 129(2-3), 2001, pp. 563-575

Abstract

To investigate the enteroinsular axis (EIA) in equines oral (oGTT) and intravenous (i.v.GTT) glucose tolerance tests (5.6 and 1 mmol glucose/kg BW, respectively) were performed with healthy, normal weight large horses and Shetland ponies. Plasma was analysed for concentrations of glucose, glucose-dependent insulinotropic polypeptide (GIP) and insulin. In all equines plasma GIP concentrations only increased significantly when glucose was administered orally. The insulin glucose ratio (IGR) was significantly higher during the oCTT than during the i.v.GTT in both races. Basal plasma glucose levels were significantly higher in large horses than in ponies in both experiments. During the oGTT maximum glucose values were significantly higher in ponies. Ponies tended to a higher insulin secretion but the IGRs were identical in both races after oral and intravenous glucose administration. One clinically inconspicuous pony showed hyperinsulinaemia and, in case of the oGTT, insulin resistance, glucose intolerance, and GIP hypersecretion. The results of this study indicate the existence of an EIA in equines due to the higher IGRs during the oGTT. Furthermore, the similarity of plasma GIP levels and IGRs in ponies and large horses suggest a comparable activity of theEIA in both races. Regarding the elevated plasma GIP concentrations of theinsulin resistant pony the EIA appears to participate in equine hyperinsulinaemia. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 25/01/20 alle ore 10:27:03