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Titolo:
Hemodynamics of local cerebral blood flow induced by somatosensory stimulation under normoxia and hyperoxia in rats
Autore:
Matsuura, T; Kashikura, K; Kanno, I;
Indirizzi:
Japan Sci & Technol Corp, Akita Lab, Akita Res Inst Brain & Blood Vessels,Akita 0100874, Japan Japan Sci & Technol Corp Akita Japan 0100874 essels,Akita 0100874, Japan Akita Res Inst Brain & Blood Vessels, Dept Radiol & Nucl Med, Akita 0100874, Japan Akita Res Inst Brain & Blood Vessels Akita Japan 0100874 0100874, Japan
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 2-3, volume: 129, anno: 2001,
pagine: 363 - 372
SICI:
1095-6433(200106)129:2-3<363:HOLCBF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER-DOPPLER MEASUREMENTS; OXYGEN-TENSION; ACTIVATION; CORTEX; CBF; VELOCITY; DIAMETER;
Keywords:
arteriole; capillary; cerebral blood flow; hemodynamics; hind-paw stimulation; hyperoxia; laser-doppler flowmetry; somatosensory activation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuura, T Japan Sci & Technol Corp, Akita Lab, Akita Res Inst Brain & Blood Vessels,6-10 Senshu Kubota Machi, Akita 0100874, Japan Japan Sci & Technol Corp 6-10 Senshu Kubota Machi Akita Japan 0100874
Citazione:
T. Matsuura et al., "Hemodynamics of local cerebral blood flow induced by somatosensory stimulation under normoxia and hyperoxia in rats", COMP BIOC A, 129(2-3), 2001, pp. 363-372

Abstract

We observed changes in the local cerebral blood how (LCBF), red blood cell(RBC) concentration and RBC velocity in a-chloralose anesthetized rats using laser-Doppler flowmetry during activation of the somatosensory cortex following electrical stimulation of the hind paw under hyperoxia (PaO2 = 513.5 +/- 48.4 mmHg; mean +/- S.D.) and normoxia (PaO2 = 106.4 +/- 8.4 mmHg). Electrical stimuli of 5 and 10 Hz (pulse width 0.1 ms) with an intensity of 1.5 mA were applied for 5 s (n = 13 at 5 Hz, n = 9 at 10 Hz). Baseline levels of LCBF and RBC concentration under hyperoxia were, respectively, 5.6 +/- 3.3 and 8.8 +/- 3.0% lower than those under normoxia (P < 0.05), and thatof RBC velocity under hyperoxia was slightly higher than that under normoxia (NS), suggesting mild vasoconstriction at rest under hyperoxia. At 5 Hz stimulation, after normalization to each baseline level, normalized response magnitudes of LCBF, RBC concentration and RBC velocity under hyperoxia were, respectively, 68.2 <plus/minus> 48.0, 71.1 +/- 65.5 and 66.0 +/- 56.3% greater than those under normoxia (P < 0.05). At 10-Hz stimulation, normalized response magnitudes of LCBF and RBC concentration under hyperoxia were,respectively, 44.6 <plus/minus> 32.0 and 55.9 +/- 43.5% greater than thoseunder normoxia (P < 0.05), although a significant difference in the normalized response magnitude of RBC velocity was not detected between both conditions. The evoked LCBF under hyperoxia increased earlier, by approximately 0.15 s, than that under normoxia regardless of the stimulus frequency (P < 0.05). These results suggest the involvement of oxygen interaction on the regulation of LCBF during neuronal activation. (C) 2001 Elsevier Science Inc. All rights: reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 05:34:19