Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Functional blockade of platelet-derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice
Autore:
Sano, H; Sudo, T; Yokode, M; Murayama, T; Kataoka, H; Takakura, N; Nishikawa, S; Nishikawa, SI; Kita, T;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Geriatr Med, Sakyo Ku, Kyoto 6068507, JapanKyoto Univ Kyoto Japan 6068507 riatr Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Dept Mol Genet, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Mol Genet, Sakyo Ku, Kyoto 6068507, Japan
Titolo Testata:
CIRCULATION
fascicolo: 24, volume: 103, anno: 2001,
pagine: 2955 - 2960
SICI:
0009-7322(20010619)103:24<2955:FBOPGF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSLUMINAL CORONARY ANGIOPLASTY; FACTOR-B CHAIN; SIGNAL-TRANSDUCTION; PDGF; ATHEROSCLEROSIS; EXPRESSION; INHIBITION; ISOFORMS; ANTIBODY; ARTERIES;
Keywords:
platelet-derived factors; aorta; atherosclerosis; plaque; antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Yokode, M Kyoto Univ, Grad Sch Med, Dept Geriatr Med, Sakyo Ku, 54 Kawahara-cho, Kyoto 6068507, Japan Kyoto Univ 54 Kawahara-cho Kyoto Japan 6068507o 6068507, Japan
Citazione:
H. Sano et al., "Functional blockade of platelet-derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice", CIRCULATION, 103(24), 2001, pp. 2955-2960

Abstract

Background-The vascular smooth muscle cell (VSMC) is the central cell component involved in the fibroproliferative response in atherogenesis. As the lesion advances, VSMCs migrate from the media into the subendothelial space, thereby forming fibrous plaque lesions. Platelet-derived growth factor (PDGF) has been known to be a potent chemoattractant and mitogen for SMCs, but the pathophysiological role of the 2 PDGF receptors, receptor-alpha (PDGFR-alpha) and receptor-beta (PDGFR-beta) in atherogenesis is poorly understood. To clarify this problem, we prepared antagonistic rat monoclonal antibodies, APA5 and APB5, against murine PDGFR-alpha and PDGFR-beta, respectively. Methods and Results-Apolipoprotein E-deficient mice were fed a high-fat diet containing 0.3% cholesterol from 6 weeks of age and subjected to injection with 1 mg/d IP of either antibody from 12 to 18 weeks every other day. In the mice injected with APB5, the aortic atherosclerotic lesion size and the number of intimal VSMCs were reduced by 67% and 80%, respectively, compared with the control mice injected with irrelevant rat IgG. In contrast, the mice that received APA5 showed only minimal reduction of lesion size, anda large number of VSMCs were observed in the intima, In the intima of advanced lesions, APB5 immunolabeled VSMCs, whereas APA5 could detect VSMCs mainly in the media,Conclusions-These results indicate that PDGFR-beta plays a significant role in formation of fibrous atherosclerotic lesions and that regulation of the signal transduction through PDGFR-beta could affect atherogenesis in mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 18:08:19