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Titolo:
Meta-analysis of rizatriptan efficacy in randomized controlled clinical trials
Autore:
Ferrari, MD; Loder, E; McCarroll, KA; Lines, CR;
Indirizzi:
Leiden Univ, Med Ctr, Dept Neurol, Leiden, Netherlands Leiden Univ Leiden Netherlands ed Ctr, Dept Neurol, Leiden, Netherlands Spalding Rehabil Hosp, Headache Management Program, Boston, MA USA Spalding Rehabil Hosp Boston MA USA e Management Program, Boston, MA USA Merck & Co Inc, W Point, PA USA Merck & Co Inc W Point PA USAMerck & Co Inc, W Point, PA USA
Titolo Testata:
CEPHALALGIA
fascicolo: 2, volume: 21, anno: 2001,
pagine: 129 - 136
SICI:
0333-1024(200103)21:2<129:MOREIR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
10 MG; 2.5 MG; MIGRAINE; SUMATRIPTAN; CROSSOVER; SAFETY;
Keywords:
rizatriptan; 5-HT1B/1D receptor agonist; migraine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Lines, CR BL 1-12,10 Sentry Pkwy, Blue Bell, PA 19422 USA BL 1-12,10 Sentry Pkwy Blue Bell PA USA 19422 ell, PA 19422 USA
Citazione:
M.D. Ferrari et al., "Meta-analysis of rizatriptan efficacy in randomized controlled clinical trials", CEPHALALGIA, 21(2), 2001, pp. 129-136

Abstract

Data from seven randomized, placebo-controlled, double-blind phase III clinical trials were analysed to further evaluate the efficacy of rizatriptan 10 mg (n=2068) in comparison with placebo (n=1260) and rizatriptan 5 mg (n=1486) for the acute treatment of a migraine attack. Migraine was diagnosed according to International Headache Society criteria. Headache severity, associated migraine symptoms and functional disability were measured immediately before dosing and at 0.5, 1, 1.5 and 2 h. Headache recurrence (return of moderate or severe headache after an initial response) was also recorded. In addition to conventional pain relief (reduction of moderate or severe headache to mild or none) and pain free measures, the analysis looked at theelimination of associated migraine symptoms and disability in patients whohad symptoms or disability at baseline. Maintenance of pain relief or pain-free status over 23 h was also analysed. At 2 h, rizatriptan 10 mg was significantly more effective than placebo for pain relief (71% vs. 38%, P<0.001), and for elimination of pain, nausea, photophobia, phonophobia and functional disability. The benefit was maintained over 24 h; 37% of patients on rizatriptan 10 mg had sustained pain relief vs. 18% for placebo (P<0.001). Rizatriptan 10 mg was also more effective than rizatriptan 5 mg, with a significant superiority at 2h on all measures except for elimination of nausea. The benefit was maintained over 24 h; 38% of patients on rizatriptan 10 mg had sustained pain relief vs. 32% for rizatriptan 5 mg (P=0.001).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:29:56