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Titolo:
A comparative study of oral acetylsalicyclic acid and metoprolol for the prophylactic treatment of migraine. A randomized, controlled, double-blind, parallel group phase III study
Autore:
Diener, HC; Hartung, E; Chrubasik, J; Evers, S; Schoenen, J; Eikermann, A; Latta, G; Hauke, W;
Indirizzi:
Univ Essen, Dept Neurol, D-45122 Essen, Germany Univ Essen Essen GermanyD-45122 en, Dept Neurol, D-45122 Essen, Germany Univ Dusseldorf, Dept Anaesthesiol, D-4000 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-4000 ol, D-4000 Dusseldorf, Germany Univ Sydney, Fac Pharm, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 Pharm, Sydney, NSW 2006, Australia Univ Munster, Dept Neurol, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 Dept Neurol, D-4400 Munster, Germany Univ Liege, Dept Neurol, Liege, Belgium Univ Liege Liege BelgiumUniv Liege, Dept Neurol, Liege, Belgium Bayer AG, Med Res, D-5090 Leverkusen, Germany Bayer AG Leverkusen Germany D-5090 , Med Res, D-5090 Leverkusen, Germany Europharma, EPA, Kronberg, Germany Europharma Kronberg GermanyEuropharma, EPA, Kronberg, Germany
Titolo Testata:
CEPHALALGIA
fascicolo: 2, volume: 21, anno: 2001,
pagine: 120 - 128
SICI:
0333-1024(200103)21:2<120:ACSOOA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUALITY-OF-LIFE; COMMON MIGRAINE; PROPRANOLOL; FLUNARIZINE; ASPIRIN; PLACEBO;
Keywords:
migraine; migraine prophylaxis; metoprolol; acetylsalicyclic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Diener, HC Univ Essen, Dept Neurol, Hufelandstr 55, D-45122 Essen, GermanyUniv Essen Hufelandstr 55 Essen Germany D-45122 Essen, Germany
Citazione:
H.C. Diener et al., "A comparative study of oral acetylsalicyclic acid and metoprolol for the prophylactic treatment of migraine. A randomized, controlled, double-blind, parallel group phase III study", CEPHALALGIA, 21(2), 2001, pp. 120-128

Abstract

This study was a multinational, multicentre, double-blind, active controlled phase III trial designed to investigate efficacy and safety of 300 mg acetylsalicyclic acid (ASA) (n = 135) vs. 200 mg metoprolol (n = 135) in the prophylaxis of migraine. In total 270 (51 male and 219 female) patients, aged 18-65 years, suffering between two and six migraine attacks per month were recruited. The main objective was to show equivalence with respect to efficacy, defined as a 50% reduction in the rate of migraine attacks. A run-in phase was carried out with placebo for 4 weeks, followed by a 16-week drug phase. In both treatment groups the median frequency of migraine attacks improved during the study period, from three to two in the ASA group and from three to one in the metoprolol group; 45.2% of all metoprolol patients were responders compared with 29.6% with ASA. Medication-related adverse events were less frequent in the ASA group (37) than in the metoprolol group (73). The findings from this trial show that metoprolol is superior to ASA for migraine prophylaxis but has more side-effects. Acetylsalicylic acid is better tolerated than metoprolol. Using a strict responder criterion ASA showed a responder rate comparable with the placebo rate in the literature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:11:21