Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neuropeptide localization in the 'migraine generator' region of the human brainstem
Autore:
Tajti, J; Uddman, R; Edvinsson, L;
Indirizzi:
Malmo Univ Hosp, Dept Otorhinolaryngol, S-20502 Malmo, Sweden Malmo Univ Hosp Malmo Sweden S-20502 hinolaryngol, S-20502 Malmo, Sweden Albert Szent Gyorgyi Univ, Sch Med, Dept Neurol, Szeged, Hungary Albert Szent Gyorgyi Univ Szeged Hungary , Dept Neurol, Szeged, Hungary Univ Lund Hosp, Dept Internal Med, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 pt Internal Med, S-22185 Lund, Sweden
Titolo Testata:
CEPHALALGIA
fascicolo: 2, volume: 21, anno: 2001,
pagine: 96 - 101
SICI:
0333-1024(200103)21:2<96:NLIT'G>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLASE-ACTIVATING POLYPEPTIDE; GENE-RELATED PEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE; SUBSTANCE-P; PERIAQUEDUCTAL GRAY; CEREBRAL-ARTERIES; BLOOD-FLOW; RAT; HEADACHE; STEM;
Keywords:
migraine; neuropeptides; immunocytochemistry; locus coeruleus; periaqueductal grey; raphe nuclei;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Uddman, R Malmo Univ Hosp, Dept Otorhinolaryngol, S-20502 Malmo, Sweden Malmo Univ Hosp Malmo Sweden S-20502 ol, S-20502 Malmo, Sweden
Citazione:
J. Tajti et al., "Neuropeptide localization in the 'migraine generator' region of the human brainstem", CEPHALALGIA, 21(2), 2001, pp. 96-101

Abstract

Evidence from animals and humans suggests that brainstem nuclei such as the raphe nuclei, the locus coeruleus (LC) and the periaqueductal grey matter(PAG), are involved in the pathophysiology of migraine. In order to understand possible neurotransmitters involved we have, by means of indirect immunocytochemistry, analysed these regions for the occurrence and distributionof calcitonin gene-related peptide (CGRP), substance P (SP), pituitary adenylate-cyclase activating peptide (PACAP) and vasoactive intestinal polypeptide (VIP). CGRP-immunoreactive (-ir) cell bodies, but no fibres, were found to occur in high numbers, constituting 80% of all nerve cell bodies in the LC. A smaller number of these nerve cell bodies (40%) in the LC proved tobe PACAP-ir. The LC neurones also stored the vesicular monoamine transporter (VMAT)- and the C-terminal flanking peptide of neuropeptide Y (C-PON)-ir, illustrating their adrenergic nature. Double immunostaining revealed thatall VMAT-and C-PON-containing neurones, in addition, stored CGRP. Immunoreactive cell bodies were not seen in the nucleus raphe magnus (NRM) or PAG. Numerous SP-ir nerve fibres were observed in the NRM, the LC and the PAG. Few PACAP-ir nerve fibres were detected in the PAG and few VIP-ir nerve fibres were seen in the NRM and the PAG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 09:34:47