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Titolo:
Transient increase in rab 3A and synaptobrevin immunoreactivity after mildhypoxia in neonatal rats
Autore:
Manzur, A; Sosa, M; Seltzer, AM;
Indirizzi:
Univ Nacl Cuyo, Fac Ciencias Med, Catedra Fisiol Patol, Lab Neuroquim, RA-5500 Mendoza, Argentina Univ Nacl Cuyo Mendoza Argentina RA-5500 uim, RA-5500 Mendoza, Argentina Univ Nacl Cuyo, Fac Ciencias Med, IHEM, RA-5500 Mendoza, Argentina Univ Nacl Cuyo Mendoza Argentina RA-5500 HEM, RA-5500 Mendoza, Argentina
Titolo Testata:
CELLULAR AND MOLECULAR NEUROBIOLOGY
fascicolo: 1, volume: 21, anno: 2001,
pagine: 39 - 52
SICI:
0272-4340(200102)21:1<39:TIIR3A>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; ISCHEMIC BRAIN-DAMAGE; DIFFERENTIAL EXPRESSION; CULTURED ASTROCYTES; PROTEIN; INJURY; SNAP-25; SYNAPTOPHYSIN; PLASTICITY; MECHANISMS;
Keywords:
neonatal hypoxia; rab 3A; synaptobrevin; GAP-43;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Seltzer, AM Univ Nacl Cuyo, Fac Ciencias Med, Catedra Fisiol Patol, Lab Neuroquim, Av Libertador S-N, RA-5500 Mendoza, Argentina Univ Nacl Cuyo Av Libertador S-N Mendoza Argentina RA-5500 na
Citazione:
A. Manzur et al., "Transient increase in rab 3A and synaptobrevin immunoreactivity after mildhypoxia in neonatal rats", CELL MOL N, 21(1), 2001, pp. 39-52

Abstract

1. In the present work we describe the short term effects of mild neonatalhypoxia on the synapse as assessed by the immunoreactivity (IR) of two synaptic proteins: rab 3A and synaptobrevin (VAMP).2. Using the sensitive methodology of immunoblotting, we measured rab 3A and VAMP-IR in homogenates from the cerebral cortex, hippocampus, and corpusstriatum of control (breathing room air) and hypoxiated (breathing 95.5% N-2-6.5% O-2 for 70 min) 4-day-old rats at 1, 2, and 6 h after the end of the hypoxia. Immunostaining with examination by light microscopy was performed using the synaptic protein-specific antibodies on fixed brain sections from animals belonging to the same litter and submitted to hypoxia.3. A transient increase of VAMP-LR was observed in the hippocampus and corpus striatum, and for rab 3A in the striatum, 1 h after initiating reoxygenation. At the following time points the values returned to control levels. This effect was less clearly observed in the immunostained sections.4. Mild hypoxia has an effect on sensitive brain regions, eliciting an increase in the IR of at least two proteins involved in the synaptic vesicle cycle. The transient nature of this effect possibly indicates the activationof endogenous neuroprotective mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:37:06