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Titolo:
Histamine deficiency suppresses murine haptoglobin production and modifieshepatic protein tyrosine phosphorylation
Autore:
Hegyi, K; Fulop, AK; Toth, S; Buzas, E; Watanabe, T; Ohtsu, H; Ichikawa, A; Nagy, A; Falus, A;
Indirizzi:
Semmelweis Univ Med, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1089 ol, H-1089 Budapest, Hungary Hungarian Acad Sci, Mol Immunol Res Grp, Budapest, Hungary Hungarian Acad Sci Budapest Hungary Immunol Res Grp, Budapest, Hungary Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Inst, Toronto, ON M5G 1X5, Canada Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Physiol Chem, Kyoto, Japan KyotoUniv Kyoto Japan Pharmaceut Sci, Dept Physiol Chem, Kyoto, Japan Tohoku Univ, Sch Med, Dept Cellular Pharmacol 1, Sendai, Miyagi 980, JapanTohoku Univ Sendai Miyagi Japan 980 harmacol 1, Sendai, Miyagi 980, Japan
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 5-6, volume: 58, anno: 2001,
pagine: 850 - 854
SICI:
1420-682X(200105)58:5-6<850:HDSMHP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE-PHASE RESPONSE; HISTIDINE-DECARBOXYLASE; GROWTH-FACTOR; CELL-LINES; NEURON SYSTEM; FACTOR-B; MOUSE; MICE; EXPRESSION; RECEPTORS;
Keywords:
histamine; knockout; acute phase protein; haptoglobin; tyrosine phosphorylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Falus, A Semmelweis Univ Med, Dept Genet Cell & Immunobiol, Nagyvarad Ter 4, H-1089Budapest, Hungary Semmelweis Univ Med Nagyvarad Ter 4 Budapest Hungary H-1089 gary
Citazione:
K. Hegyi et al., "Histamine deficiency suppresses murine haptoglobin production and modifieshepatic protein tyrosine phosphorylation", CELL MOL L, 58(5-6), 2001, pp. 850-854

Abstract

Histidine decarboxylase (HDC) synthesizes endogenous histamine from histidine in mammals. HDC-deficient mice (HDC-/-), if kept on a histamine-free diet, have no histamine in their tissues. HDC-/- mice show multiple phenotypes. In this study we show that both the constitutively expressed and turpentine-induced level of an acute-phase protein, haptoglobin, is significantly lower in the serum of HDC-/- mice compared to that of wildtype animals. This effect was abolished if HDC gene-targeted mice received histamine-rich food. No differences were found when lipopolysaccharide (LPS) was used to induce the acute-phase reaction. Using specific antibodies to phosphorylated tyrosine, we showed that protein tyrosine phosphorylation (Y-P) of similar to 50- and 26- to 27-kDa liver proteins is significantly decreased in HDC-/-mice, but that the difference was largely diminished if the animals were kept on a histamine-rich diet, suggesting that the phenotype with lower haptoglobin production is diet inducible. Upon in vivo treatment with LPS, Y-P band intensity decreased, regardless of the presence or absence of histamine. Identification of elements of the signalling pathway with decreased phosphorylation may elucidate the molecular background of the effect of endogenous histamine in the hepatic acute-phase reaction.

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Documento generato il 20/09/20 alle ore 07:03:50