Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
On the existence of cytokines in invertebrates
Autore:
Beschin, A; Bilej, M; Torreele, E; De Baetselier, P;
Indirizzi:
Free Univ Brussels, VUB, Flemish Interuniv Biotechnol, Dept Immunol Parasitol & Ultrastruct, B-1640 Rhode St Genese, Belgium Free Univ Brussels Rhode St Genese Belgium B-1640 ode St Genese, Belgium Acad Sci Czech Republ, Inst Microbiol, Dept Immunol, CR-14220 Prague 4, Czech Republic Acad Sci Czech Republ Prague Czech Republic 4 0 Prague 4, Czech Republic
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 5-6, volume: 58, anno: 2001,
pagine: 801 - 814
SICI:
1420-682X(200105)58:5-6<801:OTEOCI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; TGF-BETA SUPERFAMILY; HEPARAN-SULFATE PROTEOGLYCANS; SIGNAL-TRANSDUCTION PATHWAYS; BONE MORPHOGENETIC PROTEINS; FIBROBLAST GROWTH-FACTOR; DAUER LARVA DEVELOPMENT; HIGH-AFFINITY RECEPTOR; NF-KAPPA-B; INTERFERON-GAMMA;
Keywords:
invertebrate; cytokine; evolution; lectin; inflammation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
156
Recensione:
Indirizzi per estratti:
Indirizzo: Beschin, A Free Univ Brussels, VUB, Flemish Interuniv Biotechnol, Dept Immunol Parasitol & Ultrastruct, Paardenstr 65, B-1640 Rhode St Genese, Belgium Free Univ Brussels Paardenstr 65 Rhode St Genese Belgium B-1640
Citazione:
A. Beschin et al., "On the existence of cytokines in invertebrates", CELL MOL L, 58(5-6), 2001, pp. 801-814

Abstract

Based on the assumption that invertebrates, like vertebrates, possess factors regulating responses to infection or wounding, studies dealing with theevolution of immunity have focussed on the isolation and characterisation of putative cytokine-related molecules from invertebrates. Until recently, most of our knowledge of cytokine- and cytokine receptor-like molecules in invertebrates relies on functional assays and similarities at the physicochemical level. As such, a phylogenetic relationship between invertebrate cytokine-like molecules and vertebrate counterparts could not be convincingly demonstrated. Recent genomic sequence analyses of interleukin-1-receptor-related molecules, that is Toll-like receptors, and members of the transforming growth factor-beta superfamily suggest that the innate immune system of invertebrates and vertebrates evolved independently. In addition, data fromprotochordates and annelids suggest that invertebrate cytokine-like molecules and vertebrate factors do not have the same evolutionary origin. We propose instead that the convergence of function of invertebrate cytokine-likemolecules and vertebrate counterparts involved in innate immune defences may be based on similar lectinlike activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:57:21