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Titolo:
ATP-dependent chromatin remodeling activities
Autore:
Havas, K; Whitehouse, I; Owen-Hughes, T;
Indirizzi:
Univ Dundee, Wellcome Trust Bioctr, Div Gene Regulat & Express, Dundee DD15BY, Scotland Univ Dundee Dundee Scotland DD1 5BY t & Express, Dundee DD15BY, Scotland
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 5-6, volume: 58, anno: 2001,
pagine: 673 - 682
SICI:
1420-682X(200105)58:5-6<673:ACRA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SWI-SNF COMPLEX; HISTONE-FOLD PROTEINS; YEAST SWI/SNF COMPLEX; SACCHAROMYCES-CEREVISIAE; CELL-CYCLE; DNA METHYLATION; TRANSCRIPTIONAL REPRESSION; NUCLEOSOME MOBILITY; ACTIVE CHROMATIN; GENE-EXPRESSION;
Keywords:
ATP-dependent chromatin remodeling; SWI/SNF; gene regulation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Owen-Hughes, T Univ Dundee, Wellcome Trust Bioctr, Div Gene Regulat & Express, Dundee DD15BY, Scotland Univ Dundee Dundee Scotland DD1 5BY ndee DD15BY, Scotland
Citazione:
K. Havas et al., "ATP-dependent chromatin remodeling activities", CELL MOL L, 58(5-6), 2001, pp. 673-682

Abstract

Genetic and biochemical approaches have indicated that the packaging of DNA into chromatin can be repressive to transcription [1]. ATP-dependent chromatin remodelling activities can facilitate transcription from chromatin templates [2]. Consistent with this, biochemical assays have shown that the action of ATP-dependent chromatin remodelling activities increase the accessibility of DNA within chromatin templates [3]. However more recent functional studies suggest that many ATP-dependent chromatin remodelling activitiescan also function as repressors of transcription. Here we review recent advances to our understanding of the biological function of these complexes. We then consider some of the mechanisms by which ATP-dependent chromatin remodelling activities together with other forms of chromatin remodelling or modifying enzymes may act to regulate genomic accessibility either positively or negatively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:37:52