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Titolo:
Remyelination of demyelinated CNS axons by transplanted human Schwann cells: The deleterious effect of contaminating fibroblasts
Autore:
Brierley, CMH; Crang, AJ; Iwashita, Y; Gilson, JM; Scolding, NJ; Compston, DAS; Blakemore, WF;
Indirizzi:
Univ Cambridge, Dept Vet Clin Med, Cambridge CB3 OES, England Univ Cambridge Cambridge England CB3 OES Med, Cambridge CB3 OES, England Dept Neurol, Cambridge CB2 2PY, England Dept Neurol Cambridge England CB2 2PY Neurol, Cambridge CB2 2PY, England Cambridge Ctr Brain Repair, Cambridge CB2 2PY, England Cambridge Ctr BrainRepair Cambridge England CB2 2PY ge CB2 2PY, England Frenchay Hosp, Dept Clin Neurosci, Bristol BS16 1LE, Avon, England Frenchay Hosp Bristol Avon England BS16 1LE istol BS16 1LE, Avon, England
Titolo Testata:
CELL TRANSPLANTATION
fascicolo: 3, volume: 10, anno: 2001,
pagine: 305 - 315
SICI:
0963-6897(2001)10:3<305:RODCAB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; PROGENITOR CELLS; ADULT CNS; IN-VITRO; RAT; CULTURE; LESIONS; POPULATIONS; MYELIN;
Keywords:
human Schwann cells; Schwann cell transplantation; remyelination; fibroblasts;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Blakemore, WF Univ Cambridge, Dept Vet Clin Med, Madingley Rd, Cambridge CB3 OES, England Univ Cambridge Madingley Rd Cambridge England CB3 OES gland
Citazione:
C.M.H. Brierley et al., "Remyelination of demyelinated CNS axons by transplanted human Schwann cells: The deleterious effect of contaminating fibroblasts", CELL TRANSP, 10(3), 2001, pp. 305-315

Abstract

Areas of dermyelination can be remyelinated bp transplanting myelin-forming cells. Schwann cells are the naturally remyelinating cells of the peripheral nervous system and have a number of features that may make them attractive for cell implantation therapies in multiple sclerosis, in which spontaneous but limited Schwann cell remyelination has been well documented. Schwann cells can be expanded in vitro, potentially affording the opportunity ofautologous transplantation; and they might also be spared the demyelinating process in multiple sclerosis. Although rat, cat, and monkey Schwann cells have been transplanted into rodent demyelinating lesions, the behavior oftransplanted human Schwann cells has not been evaluated. In this study we examined the consequences of injecting human Schwann cells into areas of acute demyelination in the spinal cords of adult rats. We found that transplants containing significant fibroblast contamination resulted in deposition of targe amounts of collagen and extensive axonal degeneration. However, Schwann cell preparations that had been purified by positive immunoselection using antibodies to human low-affinity nerve growth factor receptor containing less than 10% fibroblasts were associated with remyelination. This result indicates that fibroblast contamination of human Schwann cells represents a greater problem than would have been appreciated from previous studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 01:44:37