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Titolo:
Transient protection by peripheral benzodiazepine receptors during the early events of ultraviolet light-induced apoptosis
Autore:
Stoebner, PE; Carayon, P; Casellas, P; Portier, M; Lavabre-Bertrand, T; Cuq, P; Cano, JP; Meynadier, J; Meunier, L;
Indirizzi:
Lab Drug Toxicol, Montpellier, France Lab Drug Toxicol Montpellier France b Drug Toxicol, Montpellier, France CHU Nimes, Dept Cytol & Cytogenet, Nimes, France CHU Nimes Nimes FranceCHU Nimes, Dept Cytol & Cytogenet, Nimes, France Sanofi Synthelabo Rech, Immunooncol Dept, Montpellier, France Sanofi Synthelabo Rech Montpellier France col Dept, Montpellier, France CHU Montpellier, Hop St Eloi, Dept Dermatol Allergol Photobiol, Montpellier, France CHU Montpellier Montpellier France ergol Photobiol, Montpellier, France
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 7, volume: 8, anno: 2001,
pagine: 747 - 753
SICI:
1350-9047(200107)8:7<747:TPBPBR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-C RELEASE; MITOCHONDRIAL PERMEABILITY TRANSITION; PROGRAMMED CELL-DEATH; ACTIVATION; CASPASE-3; BCL-2; REDUCTION; AMPLIFICATION; LOCALIZATION; MEMBRANE;
Keywords:
apoptosis; mitochondria; peripheral benzodiazepine receptor; ultraviolet;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Meunier, L CHU Nimes, Hop Caremeau, Dept Dermatol, Av Prof Debre, F-30900 Nimes, France CHU Nimes Av Prof Debre Nimes France F-30900 900 Nimes, France
Citazione:
P.E. Stoebner et al., "Transient protection by peripheral benzodiazepine receptors during the early events of ultraviolet light-induced apoptosis", CELL DEAT D, 8(7), 2001, pp. 747-753

Abstract

The peripheral benzodiazepine receptor (PBR) is a mitochondrial protein involved in the formation of mitochondrial permeability transition (PT) poreswhich play a critical role during the early events of apoptosis. PBRs are located in many tissues and are strongly expressed in the superficial layers of human epidermis. PBRs play a protective role against free radical damage and PER ligands modulate apoptosis, To investigate the role of PER during the early events of ultraviolet (UV)-mediated apoptosis we compared the effects of UVB on PBR-transfected Jurkat cells and their wild type counterparts devoid of any PER expression. Results indicate that early after UVB exposure (up to 4 h), PBR-transfected cells were more resistant to apoptosis and exhibited a delayed mitochondrial transmembrane potential drop, a diminished superoxide anions production, and a reduced caspase-3 activation. Taken together these findings suggest that PER may regulate early death signalsleading to UV induced apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 01:16:01