Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Functional characterization of Fas ligand on tumor cells escaping active specific immunotherapy
Autore:
Cefai, D; Schwaninger, R; Balli, M; Brunner, T; Gimmi, CD;
Indirizzi:
Univ Bern, Dept Clin Res, CH-3010 Bern, Switzerland Univ Bern Bern Switzerland CH-3010 t Clin Res, CH-3010 Bern, Switzerland Univ Bern, Inst Pathol, CH-3010 Bern, Switzerland Univ Bern Bern Switzerland CH-3010 nst Pathol, CH-3010 Bern, Switzerland
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 7, volume: 8, anno: 2001,
pagine: 687 - 695
SICI:
1350-9047(200107)8:7<687:FCOFLO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLON-CANCER CELLS; IMMUNE PRIVILEGE; IN-VIVO; TRANSGENIC MICE; MELANOMA-CELLS; BREAST-CANCER; JAM TEST; T-CELLS; EXPRESSION; APOPTOSIS;
Keywords:
HER-2/neu; tumor cell lines; immune escape; Fas ligand;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Gimmi, CD Univ Bern, Dept Clin Res, 35 Murtenstr, CH-3010 Bern, Switzerland Univ Bern 35 Murtenstr Bern Switzerland CH-3010 rn, Switzerland
Citazione:
D. Cefai et al., "Functional characterization of Fas ligand on tumor cells escaping active specific immunotherapy", CELL DEAT D, 8(7), 2001, pp. 687-695

Abstract

Mice transgenic for the rat HER-2/neu oncogene (rNeu-TG) developed spontaneous breast tumors that can escape a rNeu-specific immune response induced by active specific immunotherapy (ASI), The ability of these escape tumors to grow appeared to be due to upregulation of the Fas ligand (Fas-L) molecule. In an effort to develop tools for the better elucidation of the role ofFas-L and other regulatory mechanisms in tumor escape, we established celllines derived from escape tumors. These tumor cell lines retained MHC class I, rNeu and Fas-L expression in vitro and formed tumors in vaccinated mice, Tumor growth was accompanied by permanent Fas-L expression in vivo, bothin vaccinated and control vaccinated mice, indicating that these cells have acquired constitutive Fas-L expression. Moreover, these cells induced target cell apoptosis in vitro, Thus, these cells represent a unique tool to elucidate the importance of Fas-L expressed by tumors that escaped efficientsystemic immune responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:29:17