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Titolo:
Antioxidant activity of resveratrol in endotoxin-stimulated blood platelets
Autore:
Olas, B; Wachowicz, B; Saluk-Juszczak, J; Zielinski, T; Kaca, W; Buczynski, A;
Indirizzi:
Univ Lodz, Inst Biochem, Dept Gen Biochem, PL-90237 Lodz, Poland Univ Lodz Lodz Poland PL-90237 , Dept Gen Biochem, PL-90237 Lodz, Poland Polish Acad Sci, Ctr Microbiol & Virol, Lodz, Poland Polish Acad Sci Lodz Poland ad Sci, Ctr Microbiol & Virol, Lodz, Poland Mil Sch Med, Dept Prevent Med, Lodz, Poland Mil Sch Med Lodz PolandMil Sch Med, Dept Prevent Med, Lodz, Poland
Titolo Testata:
CELL BIOLOGY AND TOXICOLOGY
fascicolo: 2, volume: 17, anno: 2001,
pagine: 117 - 125
SICI:
0742-2091(2001)17:2<117:AAORIE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIPLATELET ACTIVITY; ACTIVATION; GENERATION; INHIBITOR; OXIDATION; RADICALS; WINE;
Keywords:
blood platelets; chemiluminescence; free radicals; LPS; resveratrol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Wachowicz, B Univ Lodz, Inst Biochem, Dept Gen Biochem, Banacha 12-16, PL-90237 Lodz, Poland Univ Lodz Banacha 12-16 Lodz Poland PL-90237 37 Lodz, Poland
Citazione:
B. Olas et al., "Antioxidant activity of resveratrol in endotoxin-stimulated blood platelets", CELL BIOL T, 17(2), 2001, pp. 117-125

Abstract

Resveratrol (3,4',5-trihydroxystilbene) is a natural molecule with antioxidant action. It is also considered to be a molecule with antiplatelet, anticancer and anti-inflammatory action. The effects of trans-resveratrol on the reactive oxygen species (ROS) generation and thiobarbituric acid-reactivesubstances (TBARS) in blood platelets induced by endotoxin (lipopolysaccharide, LPS) or thrombin were studied in vitro. The production of superoxide radicals (O-2(.)-) and other reactive oxygen species (H2O2, singlet oxygen,and organic radicals) in the presence of resveratrol was measured by a chemiluminescence method in resting blood platelets and platelets stimulated by LPS (0.3 mug/10(8) platelets) or thrombin (2.5 U/10(8) platelets). We have shown that resveratrol (6.25-100 mug/ml) inhibits chemiluminescence and generation of O-2(.)- in blood platelets. It has an inhibitory effect on theproduction of ROS and TBARS in platelets caused by LPS or thrombin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:57:58