Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cardiac myocyte nuclear size and ploidy status decrease after mechanical support
Autore:
Rivello, HG; Meckert, PC; Vigliano, C; Favaloro, R; Laguens, RP;
Indirizzi:
Fdn Favaloro, ICyCC, Div Patol, Buenos Aires, DF, Argentina Fdn Favaloro Buenos Aires DF Argentina atol, Buenos Aires, DF, Argentina Univ Nacl La Plata, Catedra Patol, La Plata, Buenos Aires, Argentina Univ Nacl La Plata La Plata Buenos Aires Argentina enos Aires, Argentina CONICET, RA-1033 Buenos Aires, DF, Argentina CONICET Buenos Aires DF Argentina RA-1033 033 Buenos Aires, DF, Argentina CIC Buenos Aires, Buenos Aires, DF, Argentina CIC Buenos Aires Buenos Aires DF Argentina , Buenos Aires, DF, Argentina
Titolo Testata:
CARDIOVASCULAR PATHOLOGY
fascicolo: 2, volume: 10, anno: 2001,
pagine: 53 - 57
SICI:
1054-8807(200103/04)10:2<53:CMNSAP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR ASSIST DEVICE; DNA CONTENT; HYPERTROPHY; CARDIOMYOPATHY; HEART; MYOCARDIUM; SECTIONS; NUMBER; LEVEL; IMAGE;
Keywords:
nuclear size; ploidy; dilated cardiomyopathy; LVAD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Rivello, HG Fdn Favaloro, ICyCC, Div Patol, Av Belgrano 1746-CP,1093AAS, Buenos Aires,DF, Argentina Fdn Favaloro Av Belgrano 1746-CP,1093AAS Buenos Aires DF Argentina
Citazione:
H.G. Rivello et al., "Cardiac myocyte nuclear size and ploidy status decrease after mechanical support", CARDIO PATH, 10(2), 2001, pp. 53-57

Abstract

Two patients with end-stage dilated cardiomyopathy of ischemic and idiopathic origin were treated with a left ventricular assist device (LVAD) as a bridge for heart transplantation. Myocardial tissue was collected during LVAD insertion and from the left ventricular apex of the explanted hearts. Themyocyte diameter, nuclear area and DNA content of myocyte nuclei were measured by static cytomorphometry in tissue sections and in isolated myocytes with a digital analysis system. The presence of apoptotic nuclei was investigated by the TdT mediated X-dUTP nick end labeling technique (TUNEL). The prolonged use of a LVAD was associated with a reduction in myocyte diameter, indicating that the LVAD may induce a reversion of myocyte hypertrophy, aprocess described as "reverse remodeling. " In addition, unloading of the heart induced a reduction in the size and DNA content of myocyte nuclei. These results suggest that the cardiomyocyte nuclei are in a dynamic state and, as it occurs with cell hypertrophy, nuclear hypertrophy and polyploidization may be a reversible phenomenon. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:23:10