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Titolo:
Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca2+- and K+-evoked serotonin release
Autore:
Kawata, Y; Okada, M; Murakami, T; Kamata, A; Zhu, G; Kaneko, S;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 4, volume: 133, anno: 2001,
pagine: 557 - 567
SICI:
0007-1188(200106)133:4<557:PDBEOC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; CALCIUM-CHANNEL BLOCKERS; IN-VIVO MICRODIALYSIS; DOPAMINE RELEASE; ION CHANNELS; NEUROTRANSMITTER RELEASE; STRIATAL DOPAMINE; CENTRAL NEURONS; CONSCIOUS RATS; N-TYPE;
Keywords:
Ca2+ channel; Na+ channel; carbamazepine; serotonin; epilepsy; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Okada, M Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 omori 0368562, Japan
Citazione:
Y. Kawata et al., "Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca2+- and K+-evoked serotonin release", BR J PHARM, 133(4), 2001, pp. 557-567

Abstract

1 To elucidate mechanisms of hippocampal serotonin release and possible mechanisms of clinical action of carbamazepine (CBZ), we determined interaction between antagonists of N-type (omega -conotoxin GVIA:GVIA), P-type (omega -agatoxin IVA:IVA) Ca2+ channels, Na+ channel (tetrodotoxin: TTX) and CBZon hippocampal basal, Ca2+- and K+-evoked serotonin releases, using microdialysis in freely moving rats.2 Basal release was reduced by TTX, GVIA and IVA (GVIA>IVA). Ca2+-evoked release was reduced by GVIA but unaffected by TTX and IVA. K+-evoked releasewas reduced by TTX, GVIA and IVA (GVIA < IVA).3 TTX inhibited actions of IVA and GVIA on respective basal and K+-evoked releases, without affecting Ca2+-evoked release.4 Perfusion with 100 <mu>M CBZ (estimated-concentration in hippocampal tissue: 19+/-2 muM) enhanced basal and Ca2+-evoked releases, but reduced K+-evoked release, whereas 1000 muM CBZ (estimated-concentration in hippocampal tissue: 188+/-16 muM) reduced three types of releases.5 Under condition of pretreatment with 100 and 1000 muM CBZ, TTX unaffected basal and K+-evoked releases. Under condition of pretreatment with 100 muM CBZ, IVA and GVIA unaffected basal and K+-evoked releases, respectively, but GVIA reduced basal, Ca2+-evoked releases and IVA also reduced K+-evokedrelease. Under condition of pretreatment with 1000 muM CBZ, GVIA unaffected three types of releases, and IVA unaffected basal release but reduced K+-evoked release.6 These findings contribute towards the possible mechanisms of concentration-dependent antiepileptic action of CBZ, which possibly inhibits Na+ channel related neurotransmitter release mechanisms during K+-evoked stage, and simultaneously enhances N-type Ca2+ channel related basal serotonin releaseat the resting stage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:04:05