Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
p27 expression correlates with short-term, but not with long-term prognosis in breast cancer
Autore:
Leivonen, M; Nordling, S; Lundin, J; von Boguslawski, K; Haglund, C;
Indirizzi:
Peijas Hosp, Dept Surg, SF-01400 Vantaa, Finland Peijas Hosp Vantaa Finland SF-01400 Dept Surg, SF-01400 Vantaa, Finland Univ Helsinki, Dept Pathol, Helsinki, Finland Univ Helsinki Helsinki Finland Helsinki, Dept Pathol, Helsinki, Finland Univ Helsinki, Dept Oncol, Helsinki, Finland Univ Helsinki Helsinki Finland Helsinki, Dept Oncol, Helsinki, Finland Univ Helsinki, Cent Hosp, Dept Surg, Helsinki, Finland Univ Helsinki Helsinki Finland Cent Hosp, Dept Surg, Helsinki, Finland
Titolo Testata:
BREAST CANCER RESEARCH AND TREATMENT
fascicolo: 1, volume: 67, anno: 2001,
pagine: 15 - 22
SICI:
0167-6806(200105)67:1<15:PECWSB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
KINASE INHIBITOR P27; CELL-CYCLE; P27(KIP1) EXPRESSION; FOLLOW-UP; CARCINOMAS; SURVIVAL;
Keywords:
breast neoplasms; immunohistochemistry; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Leivonen, M Peijas Hosp, Dept Surg, Sairaalakatu 1, SF-01400 Vantaa, Finland Peijas Hosp Sairaalakatu 1 Vantaa Finland SF-01400 a, Finland
Citazione:
M. Leivonen et al., "p27 expression correlates with short-term, but not with long-term prognosis in breast cancer", BREAST CANC, 67(1), 2001, pp. 15-22

Abstract

New prognostic and predictive factors are needed to adjust more appropriate therapy for individual patients after operation. p27 is a cell cycle regulator, and a low tissue expression of this protein has been shown to correlate with poor prognosis in colorectal, lung, gastric, prostate, and breast cancer. In this study on 197 breast cancer patients with a median follow-upof 17 years, the prognostic value of immunohistochemical p27 expression was evaluated. After 5 years of follow-up patients with a p27 expression in less than 50% of the tumor cells had a significantly lower survival rate than those with an expression above this level (p = 0.01). However, after longer follow-up the difference decreased and was no longer significant at 7 years (p = 0.1) or when the entire follow-up period was examined (p = 0.67). Tests for associations showed that a low p27 expression correlated with a high histologic grade, a high S-phase fraction (SPF), an advanced TNM stage and negative hormone receptor status. In conclusion: Tissue expression of p27 is a significant predictor of 5-year, but not of 10- or 15-year breast cancer specific survival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:34:11