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Titolo:
Towards micro electrode implants: in vitro guidance of rat spinal cord neurites through polyimide sieves by Schwann cells
Autore:
Schlosshauer, B; Brinker, T; Muller, HW; Meyer, JU;
Indirizzi:
Univ Tubingen, NMI Nat Wissensch, D-72770 Reutlingen, Germany Univ Tubingen Reutlingen Germany D-72770 ch, D-72770 Reutlingen, Germany Univ Tubingen, Inst Med, D-72770 Reutlingen, Germany Univ Tubingen Reutlingen Germany D-72770 ed, D-72770 Reutlingen, Germany Krankenhaus Nordstadt, D-3000 Hannover, Germany Krankenhaus Nordstadt Hannover Germany D-3000 , D-3000 Hannover, Germany Univ Dusseldorf, Neurol Klin, D-4000 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-4000 in, D-4000 Dusseldorf, Germany Fraunhofer Inst Biomed Engn, St Ingbert, Germany Fraunhofer Inst Biomed Engn St Ingbert Germany ngn, St Ingbert, Germany
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 903, anno: 2001,
pagine: 237 - 241
SICI:
0006-8993(20010608)903:1-2<237:TMEIIV>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-NERVE REGENERATION; MICROELECTRODE ARRAY; RADIAL GLIA; STIMULATION; OUTGROWTH; SURFACE; RETINA; GROWTH;
Keywords:
axon guidance; fibroblast; polyimide implant; rat spinal cord; regeneration; Schwann cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Schlosshauer, B Univ Tubingen, NMI Nat Wissensch, Markwiesenstr 55, D-72770 Reutlingen, Germany Univ Tubingen Markwiesenstr 55 Reutlingen Germany D-72770
Citazione:
B. Schlosshauer et al., "Towards micro electrode implants: in vitro guidance of rat spinal cord neurites through polyimide sieves by Schwann cells", BRAIN RES, 903(1-2), 2001, pp. 237-241

Abstract

Our goal is to develop biohybrid neural microprobe implants with sieve electrodes for external stimulation of co-implanted neurons whose axons penetrate through the holes of electrodes and innervate host targets such as denervated muscle fibers. For evaluation of implants, potential scar formation was imitated in fibroblast-spinal cord co-cultures. In vitro neurite extension through flexible 10-mum thick polyimide sieves was inhibited by co-cultured fibroblasts. In contrast, the neurite penetration of sieves could be greatly stimulated by oriented exposure to Schwann cells. To our knowledge this is the first direct proof that Schwann cells display a guidance effect on spinal cord neurons in vitro. The results pave the way for novel biohybrid neuro-implants and provide means to circumvent the obstacle of inhibitory scar formation. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:53:25