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Titolo:
Opioid neurotransmission in the post-ictal analgesia: Involvement of mu(1)-opioid receptor
Autore:
Coimbra, NC; Freitas, RL; Savoldi, M; Castro-Souza, C; Segato, EN; Kishi, R; Weltson, A; Resende, GCC;
Indirizzi:
USP, Fac Med Ribeirao Preto, Dept Farmacol, Lab Neuroanat & Neuropsicobiol, BR-14049900 Ribeirao Preto, SP, Brazil USP Ribeirao Preto SP Brazil BR-14049900 BC900 Ribeirao Preto, SP, Brazil
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 903, anno: 2001,
pagine: 216 - 221
SICI:
0006-8993(20010608)903:1-2<216:ONITPA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFERIOR COLLICULUS; PERIAQUEDUCTAL GRAY; ELECTRICAL-STIMULATION; SUPERIOR COLLICULUS; WISTAR RATS; CONVULSIONS; MORPHINE; BLOCKADE; EPILEPSY; MU;
Keywords:
post-ictal analgesia; pentylenetetrazol; GABA-A receptor; endogenous opioids; mu(1)-opioid receptor; tail-flick test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Coimbra, NC USP, Fac Med Ribeirao Preto, Dept Farmacol, Lab Neuroanat & Neuropsicobiol, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP, BrazilUSP Ave Bandeirantes 3900 Ribeirao Preto SP Brazil BR-14049900 BC
Citazione:
N.C. Coimbra et al., "Opioid neurotransmission in the post-ictal analgesia: Involvement of mu(1)-opioid receptor", BRAIN RES, 903(1-2), 2001, pp. 216-221

Abstract

Pentylenetetrazol (PTZ), a non-competitive antagonist that blocks GABA-mediated Cl- flux, was used in the present work to induce seizures in animals. The aim of this work is to study the neurochemical basis of the antinociception induced by convulsions elicited by peripheral administration of PTZ (64 mg/kg). The analgesia was measured by the tail-flick test, in eight ratsper group. Convulsions were followed by significative increase in the tail-flick latencies (TFL), for at least 120 min of the post-ictal period, peripheral administration of naltrexone (5 mg/kg, 10 mg/kg and 20 mg/kg) causeda significant decrease in the TFL in seizing animals, as compared to controls. These data were corroborated with peripheral administration of naloxonazine ( 10 mg/kg and 20 mg/kg), a mu (1)-opioid blocker, in the same doses used for non-specific antagonist. These results indicate that endogenous opioids may be involved in the post-ictal analgesia. The involvement of mu (1)-opioid receptor was also considered. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:25:35