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Titolo:
(S)-4C3HPG, a mixed group I mGlu receptor antagonist and a group II agonist, administered intrastriatally, counteracts parkinsonian-like muscle rigidity in rats
Autore:
Lorenc-Koci, E; Wardas, J; Wolfarth, S; Pilc, A;
Indirizzi:
Polish Acad Sci, Inst Pharmacol, Dept Neuropsychopharmacol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 harmacol, PL-31343 Krakow, Poland Polish Acad Sci, Inst Pharmacol, Dept Neurobiol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 eurobiol, PL-31343 Krakow, Poland
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 903, anno: 2001,
pagine: 177 - 184
SICI:
0006-8993(20010608)903:1-2<177:(AMGIM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; SYMPATHETIC PREGANGLIONIC NEURONS; PHENYLGLYCINE DERIVATIVES; STRETCH REFLEX; MESSENGER-RNA; SPINAL-CORD; DISEASE; LOCALIZATION; EXCITATION; EXPRESSION;
Keywords:
group I metabotropic glutamate receptor; group II metabotropic glutamate receptor; parkinsonism; muscle rigidity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Lorenc-Koci, E Polish Acad Sci, Inst Pharmacol, Dept Neuropsychopharmacol,12 Smetna St, PL-31343 Krakow, Poland Polish Acad Sci 12 Smetna St KrakowPoland PL-31343 Poland
Citazione:
E. Lorenc-Koci et al., "(S)-4C3HPG, a mixed group I mGlu receptor antagonist and a group II agonist, administered intrastriatally, counteracts parkinsonian-like muscle rigidity in rats", BRAIN RES, 903(1-2), 2001, pp. 177-184

Abstract

The aim of the present study was to determine whether S-4-carboxy-3-hydroxyphenylglycine (S)-4C3HPG, a mixed group I glutamate metabotropic receptor antagonist and a group II agonist, attenuated parkinsonian-like muscle rigidity in rats. Muscle tone was examined using a combined mechano and electromyographic method, which measured simultaneously the muscle resistance (MMG) of the rat's hind foot to passive extension and flexion in the ankle joint and the electromyographic activity (EMG) of the antagonistic muscles of that joint: gastrocnemius and tibialis anterior. Muscle rigidity was inducedby pretreatment with haloperidol (1 mg/k_p i.p.). (S)-4C3HPG injected in doses of 5 and 15 mug/0.5 mul bilaterally, into the rostral region of the striatum, decreased both the haloperidol-induced muscle rigidity (MMG) and the enhanced electromyographic activity (EMG). The present results suggest that blockade of mGluR1 receptors and/or activation of mGluR2 ones, localizedin the rostral part of the striatum, may be responsible for the anti-parkinsonian effect of (S)-4C3HPG. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:24:16